浙江医学2018，Vol.40Issue(1)：19-22,4.DOI:10.12056/j.issn.1006-2785.2017.40.1.2017-717
ADAMTS-1基因多态性与汉族人群原发性高血压相关性研究
Association of ADAMTS1 gene polymorphism with essential hypertension in Han population
吕晨铃 1陈超 2郑周 3刘鹏 3何欣威 3金笑平3
作者信息
- 1. 310012杭州,浙江省立同德医院神经内科
- 2. 浙江中医药大学附属第二医院心血管内科
- 3. 台州医院神经内科
- 折叠
摘要
Abstract
Objective To assess the association of a disintegrin and metallo-proteinase with thrombospondin type one motifs(ADAMTS1) gene polymorphism with essential hypertension (EH) in Zhejiang Han population.Methods The study enrolled 469 EH patients and 229 normotensive subjects (NT) from Zhejiang Han population.DNA was isolated from the peripheral blood cells using a human blood DNA extraction kit.The single nucleotide polymorphisms (SNP) rs402007 (G/C) were genotyped by polymerase chain reaction (PCR) and DNA sequencing.Hardy-Weinberg equilibrium was used to detect group representation of study population,Results The frequency of rs402007 GC+CC and the C allele were significantly different between the two groups (74.20％ vs.65.50％,x2=5.695,P=0.020,0R=1.515;47.44％ vs.40.61％,x2=5.796,.P=0.016,OR=1.320).Binary logistic regression showed that the difference above was still significant (P=-0.028,OR=1.809,95％CI:1.067-3.067).Conclusion The rs402007 polymorphism of ADAMTS-1 may be associated with essential hypertension in Han population and the C allele may be a genetic susceptibility factor.关键词
ADAMTS-1/基因多态性/原发性高血压Key words
ADAMTS-1/Gene polymorphism/Essential hypertension引用本文复制引用
吕晨铃,陈超,郑周,刘鹏,何欣威,金笑平..ADAMTS-1基因多态性与汉族人群原发性高血压相关性研究[J].浙江医学,2018,40(1):19-22,4.
