浙江医学2018，Vol.40Issue(1)：68-70,101,4.DOI:10.12056/j.issn.1006-2785.2018.40.1.2017-695
女性系统性红斑狼疮患者血清25-羟基维生素D水平变化的临床意义
Serum 25-hydroxyl vitamin D in female patients with systemic lupus erythematosus and its clinical significance
徐晓作 1李素蘋 1项光博 1金珍木 1陈杨畅 1章丽和 1方荣伟1
作者信息
摘要
Abstract
Objective To investigate serum 25-hydroxyl vitamin D (25-OH-D) levels in female patients with systemic lupus erythematosus (SLE) and its clinical significance.Methods Seventy five female SLE patients (SLE group) and 70 cases healthy females (control group) were enrolled in the study.Serum 25-OH-D levels were detected with ECL method.The correlation of 25-OH-D levels with SLE disease activity index (SLEDAI),complement C3,complement C4,calcium (Ca),phosphorus(P),alkaline phosphatase(ALP),parathyroid hormone(PTH),24 h urinary protein(24Pro) and administration of hormone,hydroxychloroquine were analyzed with Pearson analysis.Results Serum 25-OH-D levels in the female SLE patients were significantly lower than those in control group.Serum 25-OH-D was negatively correlated with SLEDAI (r =-0.61,P＜0.01),dosage of hormone (r=-0.68,P =0.02),duration of prednisone (r=-0.74,P=0.04),24 pro (r=-0.37,P＜0.05),and positively correlated with Ca (r=0.247,P=0.042).No correlation was found between 25-OH-D and C3,C4,ALP,PTH,hydroxychloroquine.Logistic regression analysis indicated that compared to normal 25-OH-D level (≥30ng/ml),25-OH-D ＜10 ng/ml was associated with increased SLEDAI(OR=5.6,95％CI:1.146-27.37,P=0.033).Conclusion Serum levels of 25-OH-D in female SLE patients are significantly decreased,which are closely corelated with disease activity,administration of hormones and renal damage.关键词
25-羟基维生素D/系统性红斑狼疮/相关性Key words
25-OH-D/Systemic lupus erythematosus/Correlation引用本文复制引用
徐晓作,李素蘋,项光博,金珍木,陈杨畅,章丽和,方荣伟..女性系统性红斑狼疮患者血清25-羟基维生素D水平变化的临床意义[J].浙江医学,2018,40(1):68-70,101,4.
