浙江医学2018，Vol.40Issue(2)：138-141,4.DOI:10.12056/j.issn.1006-2785.2018.40.2.2017-306
卵巢未成熟型畸胎瘤治疗后肿瘤标志物的变化及其与预后的关系
Application of multiple tumor markers in management of ovarian immature teratoma
摘要
Abstract
Objective To evaluate the application of multiple tumor markers in the management of ovarian immature teratoma.Methods The clinical data of 80 patients with ovarian mature teratoma,28 patients with ovarian immature teratoma and 7 patients with malignant transformation of ovarian mature teratoma admitted in Jiaxing Maternal and Child Healthcare Centre between January 2005 and December 2015,were retrospectively reviewed.The relationship of serum levels of multiple tumor markers with the therapeutic response and prognosis of patients was analyzed.Results Compared with the mature teratoma,the serum level of AFP,CA125 and CA19-9 in ovarian immature teratoma patients were significantly higher (all P＜0.05).After surgical treatment serum AFP,SCC and CA19-9 levels significantly decreased in patients with immature teratoma (all P＜0.05),and after 3 courses of chemotherapy the levels of AFP and CEA were further decreased (both P＜0.05).The AFP level in patients with favorable prognosis after treatment were lower than those with poor prognosis (P＜0.05),however,there were no significant differences in preoperative levels of other serum markers between patients with favorable prognosis and those with poor prognosis (all P ＞0.05).Conclusion The changes of serum AFP levels after treatment have a certain clinical value for the prediction of prognosis in patients with ovarian immature teratoma.关键词
卵巢未成熟畸胎瘤/卵巢成熟畸胎瘤/肿瘤标志物/预后Key words
Ovarian immature teratoma/Ovarian mature teratoma/Tumor markers/Prognosis引用本文复制引用
杨文娟,陆婕,许胜峰..卵巢未成熟型畸胎瘤治疗后肿瘤标志物的变化及其与预后的关系[J].浙江医学,2018,40(2):138-141,4.
