浙江医学2018，Vol.40Issue(2)：148-151,4.DOI:10.12056/j.issn.1006-2785.2018.40.2.2017-1358
急性脑梗死患者不同剂量阿托伐他汀治疗后血清脂肪因子水平与脑功能恢复的关系研究
Correlation between serum adipocytokines levels and recovery of neural function in patients with acute cerebral infarction following atorvastatin treatment
摘要
Abstract
Objective To analyze the correlation between serum levels of adipocytokines and recovery of neural function in patients with acute cerebral infarction following atorvastatin treatment.Methods One-hundred and ninety-two patients with acute cerebral infarction (ACI) were divided into three groups randomly with 64 cases in each group:control group,low dose atorvastatin group and high dose atorvastatin group.Serum levels of adipocytokines chemerin,APN and vaspin were measured and neurological scores FMA,NIHSS and Barthel were evaluated before and 2 months after treatment.Results The serum levels of chemerin in high dose atorvastatin group were lower and APN and vaspin were higher than those in control group and low dose atorvastatin group (P＜0.05).The NIHSS scores in high dose group was lower,and the FMA and Barthel scores were higher than those in control group (P＜0.05).The serum adipocytokines levels and neurological scores in both high dose and low dose atorvastatin groups were improved after treatment (P＜0.05).The variation of adipocytokines (△ chemerin,△Vaspin and △APN) were significantly correlated with the variation of neurological scores (△ FMA,△ NIHSS and △ Barthel).Conclusion Atorvastatin may improve the abnormal fluctuation of adipocytokines chemerin,APN and vaspin and enhance the neural functional recovery in patients with acute cerebral infarction.关键词
急性脑梗死/阿托伐他汀/脂肪因子/脑功能恢复Key words
Acute cerebral infarction/Atorvastatin/Adipocytokines/Neural functional recovery引用本文复制引用
宫丽,曹雄彬,卢振,兰艳,胡智安,刘雅芳,孙元平,邢思思..急性脑梗死患者不同剂量阿托伐他汀治疗后血清脂肪因子水平与脑功能恢复的关系研究[J].浙江医学,2018,40(2):148-151,4.基金项目
黄石市医药卫生科技研究项目(2013-47) （2013-47）
