中山大学学报（自然科学版）（中英文）2017，Vol.56Issue(6)：128-133,6.DOI:10.13471/j.cnki.acta.snus.2017.06.020
麦冬寡糖对自发性2型糖尿病db/db小鼠降血糖的作用
The hypoglycemic effect of Ophiopogonis japonicus oligosaccharide on db/db diabetic mice
摘要
Abstract
In order to investigate the hypoglycemic effect of Ophiopogonis japonicus oligosaccharide on type 2 diabetes mellitus,the db/db diabetic mice were intragastrically administered with Ophiopogonis japonicus oligosaccharide for 8 weeks.The body weight and general physical signs were observed during the treatment.The fasting blood glucose levels were determined after 4 and 8 weeks of administration.The changes in 24 h urinary albumin excretion and 24 h urine protein amounts,glycosylated serum protein (GSP),total cholesterol (TC),triglyceride (TG),high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C),urea nitrogen and creatinine levels in serum were measured after 8 weeks of treatment.Results showed that Ophiopogonis japonicus oligosaccharide could significantly lower the body weights,blood glucose levels and the AUCs during oral glucose tolerance test,and inhibited the changes of 24 h urinary albumin excretion and 24 h urine protein amounts,GSP,TC,TG,HDL-C and LDL-C,urea nitrogen and creatinine levels in serum of db/db diabetic mice by comparison with db/m mice.In conclusion,Ophiopogonis japonicus oligosaccha.ride exerts remarkable hypoglycemic and protective effects in db/db mice,thus showing its potential for use in the treatment of type 2 diabetes mellitus.关键词
麦冬寡糖/2型糖尿病/db/db小鼠/降血糖作用Key words
Ophiopogonis japonicus oligosaccharide/type 2 diabetes mellitus/db/db mice/hypoglycemic effect分类
医药卫生引用本文复制引用
吴万征,苏薇薇,王永刚,彭维,吴忠,李沛波..麦冬寡糖对自发性2型糖尿病db/db小鼠降血糖的作用[J].中山大学学报（自然科学版）（中英文）,2017,56(6):128-133,6.基金项目
广州市科技计划项目(201704020119) （201704020119）
广东省重大科技专项资金项目(2013A022100022) （2013A022100022）
