中山大学学报（医学科学版）2018，Vol.39Issue(2)：186-191,219,7.
舌鳞状细胞癌中环状RNA的表达谱特征
Expression Profile of CircularRNA in Tongue Squamous Cell Carcinoma
摘要
Abstract
[Objective]To analyze the expression profile variation of circle RNA(circRNA)in tongue squamous cell carcinoma(TSCC)tissue and para-carcinoma tissue.[Methods]CircRNA microarray technology was performed to in-spect the difference of circRNA expression in 4 cases of TSCC tissues and 4 cases of para-carcinoma tissues,and then make analysis after the quality control and homogenization of raw data,to identify which have more than 2 times variation and significant difference(P<0.05)by statistical analysis as circRNA with differential expression. To perform functional analysis on circRNA with differential expression.[Results]Compared with para-carcinoma tissue,there were 17171 circRNA differentially expressed in TSCC tissue,while 9982 increase more than 2 times and 7189 reduce more than 2 times.[Conclusion]circRNA expression profile in TSCC changes significantly comparing with the para-carcinoma tis-sue,some differentially expressed circRNA may regulate the occurrence and progression of TSCC through a competitive combination of miRNA.关键词
环状RNA/舌鳞状细胞癌/circRNA芯片Key words
circle RNA/tongue squamous cell carcinoma(TSCC)/circRNA microarray分类
医药卫生引用本文复制引用
邹艾灵,赵建江,孙翔,贾搏,韩久松,邱小玲,褚洪星..舌鳞状细胞癌中环状RNA的表达谱特征[J].中山大学学报（医学科学版）,2018,39(2):186-191,219,7.基金项目
国家自然科学基金(81670950) （81670950）
广东省科技计划项目(2013B021800153) （2013B021800153）
广州市科技惠民专项项目(2014Y2-00109) （2014Y2-00109）
广东省自然科学基金(2015A030313787) （2015A030313787）
