北京中医药大学学报2018，Vol.41Issue(3)：216-221,6.DOI:10.3969/j.issn.1006-2157.2018.03.008
新乌头碱脂质体制备工艺的研究
Preparation technology for liposome of new aconitine
摘要
Abstract
Objective To study and optimize the preparation technology and prescription of liposome of new aconitine aiming at reducing toxicity, improving efficiency, and being suitable for industrial production with higher stability. Methods The liposome of new aconitine was prepared by using freeze-drying method, and its prescription and preparation technology were optimized by using single-factor experiment. The encapsulation efficiency(EE) and particle size were taken as review indexes,the EE of liposome of new aconitine was determined by using centrifugation and centrifugation conditions were investigated. Results The best prescription included that ratio of lecithin to cholesterol was 3:1,ratio of drug to lipid was 1:20,ratio of sugar to lipid was 5:1,and ratio of organic solvent to water was 1:3. The centrifugal conditions for determining EE were 2 000 r/min and centrifugation time was for 5 min. Under these conditions,the free drug could be separated from the drug-containing liposome. Conclusion The liposome of new aconitine obtained by this technology has reasonable prescription, feasible process and higher EE and stability.关键词
新乌头碱/脂质体/冷冻干燥法/制备工艺Key words
new aconitine/liposome/freeze-drying method/preparation technology分类
医药卫生引用本文复制引用
李洋,王秀丽..新乌头碱脂质体制备工艺的研究[J].北京中医药大学学报,2018,41(3):216-221,6.基金项目
国家中医药管理局临床中药学重点学科项目,国家中医药管理局临床药学重点学科项目(No.ZP0101YX001)Key Discipline of Clinical Chinese Materia Medica,Key Discipline of Clinical Pharmacy of State Administration of Traditional Chinese Medicine(No.ZP0101YX001) （No.ZP0101YX001）
