川北医学院学报2018，Vol.33Issue(1)：63-65,3.DOI:10.3969/j.issn.1005-3697.2018.01.019
大鼠脾脏主要结构的发育:2月、2年和3年龄的形态定量研究
Development of key structures in the rat spleen: a morphometric study at 2 months and 2 to 3 years of age
摘要
Abstract
Objective:The authors recently performed a quantitative study on the total volumes of key splenic structures in rats aged 1 day,1 month and 3~12 months,the present paper aimed to additionally study the same cohort of animals at ages of 2 months, 2 years and 3 years.Methods:Spleens were removed from the same cohort of normal male Sprague-Dawley rats,previously at age of 2 months (9 rats) and later at ages of 2 years (9 rats) and 3 years (8 rats),methacrylate resin-embedded sections were obtained,and the total volumes of key histological structures were estimated using stereological methods.Results:All key structures had been formed in the rat spleen at 2 months of age.From the age of 2 months to 2 years,the mean of splenic volumes increased by 46%.From the age of 2 to 3 years,the mean of splenic volumes decreased by 9%.There were no significant differences between the three age groups in the volume percentages of the red pulp (70% ~76%) or white pulp (17% ~21%) in the spleen.Conclusions:Development of the rat spleen reaches maturity at 2 months of age,and there is still no sign of marked atrophy up to 2~3 years of age.关键词
大鼠/脾脏/发育/组织学/形态定量/体视学Key words
Rat/Spleen/Development/Histology/Morphometry/Stereology分类
医药卫生引用本文复制引用
李阳友,黄静,郭洋,项涛,吴大鹏,陈丹,杨正伟..大鼠脾脏主要结构的发育:2月、2年和3年龄的形态定量研究[J].川北医学院学报,2018,33(1):63-65,3.基金项目
川北医学院科研发展计划项目(CBY13-A-ZP09、CBY13-A-ZP05) （CBY13-A-ZP09、CBY13-A-ZP05）
