川北医学院学报2018，Vol.33Issue(1)：94-97,104,5.DOI:10.3969/j.issn.1005-3697.2018.01.028
胸腺肽联合奥沙利铂对肺癌恶性胸腔积液患者的疗效和血清炎性因子及T淋巴细胞的影响
Effects of thymosin combined with oxaliplatin on clinical efficacy,serum inflammatory factors and T lymphocyte in patients with malignant pleural effusion of lung cancer
王正洪 1方亮 1蒋明东 1尹晓玲1
作者信息
- 1. 重庆市第九人民医院,重庆 北碚 400700
- 折叠
摘要
Abstract
Objective:To observe the clinical efficacy of thymosin combined with oxaliplatin in the treatment of patients with malignant pleural effusion (MPE) of lung cancer. The changes of serum C-reactive protein (CRP),procalcitonin (PCT) and T lym-phocyte subsets were analyzedMethods:90 patients with lung cancer and MPE were randomly divided into control group(n=45) and observation group (n=45).Both groups were treated with thoracic catheter drainage.On the basis of this,the control group was treated with oxaliplatin in the thoracic cavity,and the observation group was given oxaliplatin combined with thymosin.The levels of CRP,PCT and T lymphocyte subsets were measured in all subjects.Results:After treatment,the clinical effective rate was 88.89% and the dis-ease control rate was 95.56%,which were higher than those of the control group.The differences were statistically significant (P<0.05).There was no significant difference in serum CRP and PCT level between the two groups before treatment (P>0.05).After treatment,the levels of CRP and PCT in the two groups were significantly lower than those before treatment(P<0.05).And the obser-vation group was significantly lower than those in the control group,the difference was statistically significant(P<0.05).There was no significant difference in T lymphocyte subsets between the two groups before treatment(P>0.05).After treatment,the levels of CD4 +and CD4 +/ CD8 +in the two groups were significantly higher than those before the treatment (P<0.05).The observation group was significantly higher than those in the control group after treatment,and the difference was statistically significant(P<0.05).There was no significant difference in CD8 +level between the two groups before and after treatment (P>0.05).Conclusions:Thymosin com-bined with oxaliplatin has a significant clinical effect in the treatment of malignant pleural effusion of lung cancer.It can effectively re-duce the systemic inflammatory response,improve the level of T lymphocyte subsets and promote the recovery of immune function.It is a potentially effective clinical solution.关键词
胸腺肽/奥沙利铂/肺癌恶性胸腔积液/炎性因子/T淋巴细胞Key words
Thymosin/Oxaliplatin/Malignant Pleural Effusion/Inflammatory factor/T lymphocyte分类
医药卫生引用本文复制引用
王正洪,方亮,蒋明东,尹晓玲..胸腺肽联合奥沙利铂对肺癌恶性胸腔积液患者的疗效和血清炎性因子及T淋巴细胞的影响[J].川北医学院学报,2018,33(1):94-97,104,5.
