川北医学院学报2018，Vol.33Issue(1)：98-100,3.DOI:10.3969/j.issn.1005-3697.2018.01.029
静脉注射亚甲蓝缓解丙泊酚注射痛的临床研究
Clinical research of intravenous administration of methylene blue reducing the pain associated with propofol intravenous injection
周裕凯 1王瑛 1张先杰 1夏乐强 1韩佳1
作者信息
- 1. 德阳市人民医院麻醉科,四川 德阳 618000
- 折叠
摘要
Abstract
Objective:To investigate the efficacy and safety of intravenous methylene blue reducing the pain associated with propofol injectionMethods:180 patients aged 18-50 years old,ASAⅠ-Ⅱ,were randomly and equally divided into 3 groups:two test groups (group M and group L) and one control group(group C).Methylene blue 20mg and 2% lidocaine 40mg were given separately in group M and group L before injection of propofol. Meanwhile,the same volumetric normal saline was injected in group C.1% propo-fol was intravenously injected with a rate of 0.5 ml/s until patients lost consciousness.The frequency and severity of propofol injection pain were documented with a Ambesh 4-point scale.All patients were followed up by phone call about adverse reactions after 1 d.Re-sults:178 of 180 patients were completed and enrolled in the study. The rate of injection pain was 91.5% in group C, significantly higher than the rates of the two test groups,respectively (P<0.017,40.0% in group M and 27.1% in group L). But no statistical difference was found between the two test groups in the rate of injection pain.Group C mainly presented with a moderate-severe pian, but the two test groups only showed a mild-moderate injection pain.All patients declared no adverse reactions happened by telephone interview excepted 2 patients refused.Conclusions:Methylene blue may replaced lidocaine to effectively reduced the pain of propofol intravenous injection.关键词
亚甲蓝/丙泊酚/注射痛Key words
Methylene blue/Propofol/Injection pain分类
医药卫生引用本文复制引用
周裕凯,王瑛,张先杰,夏乐强,韩佳..静脉注射亚甲蓝缓解丙泊酚注射痛的临床研究[J].川北医学院学报,2018,33(1):98-100,3.
