重庆医学2017，Vol.46Issue(35)：4946-4948,3.DOI:10.3969/j.issn.1671-8348.2017.35.015
普伐他汀改善2型糖尿病合并高血压患者颈动脉粥样硬化研究
Study on pravastatin for improving carotid atherosclerosis in patients type 2 diabetes mellitus complicating hypertension
摘要
Abstract
Objective To explore the effect of pravastatin on carotid atherosclerosis in the patients with type 2 diabetes mellitus (T2DM) complicating hypertension.Methods One hundred and six patients.with T2DM complicating hypertension treated in this hospital from April 2015 to April 2016 were selected and divided into the conventional treatment group (n=52) and pravastatin group (n=54).The patients of conventional treatment group were given the conventional therapy of diet control,reducing blood glucose,controlling hypertension,symptomatic and support treatment,while on the basis of conventional therapy the patients of pravastatin group were added with pravastatin.The carotid intima-medial thickness (IMT),detection rate of carotid atherosclerotic plaque and carotid plaque score were measured by ultrasound before and after the treatment in all cases.Meanwhile the levels of serum lipid and hyper sensitive C reactive protein (hs-CRP) were determined.Results The above indicators in the conventional treatment group had no statistically significant difference between before and after treatment (P＞0.05),but the IMT value,detection rate of carotid atherosclerotic plaque and carotid plaque score after treatment in the pravastatin group were decreased compared with before treatment,the levels of serum total cholesterol (TC),triacylglycerol (TG),low density lipoprotein cholesterol (LDL-C) and hs-CRP were also significantly reduced compared with before treatment,the differences were statistically significant (P＜0.05),moreover the above indicators after treatment in the pravastatin group were remarkably lower than those in the conventional treatment group (P＜0.05).There was no statistically significant difference in the incidence rate of adverse reactions between the two groups (P＞0.05).Conclusion Pravastatin can effectively and safely improve the carotid atherosclerosis degree in the patients with T2DM complicating hypertension.关键词
普伐他汀/糖尿病,2型/高血压/动脉粥样硬化/高敏C反应蛋白Key words
pravastatin/diabetes mellitus, type 2/hypertension/atherosclerosis/hs-CRP分类
医药卫生引用本文复制引用
刘璟瑜,汪洋,康力,贺攀峰,何辉,张莉,刘强,周健,赵明生,陆静,钟伟..普伐他汀改善2型糖尿病合并高血压患者颈动脉粥样硬化研究[J].重庆医学,2017,46(35):4946-4948,3.基金项目
四川省卫生厅科研项目(110057). （110057）
