重庆医学2018，Vol.47Issue(9)：1200-1203,4.DOI:10.3969/j.issn.1671-8348.2018.09.016
MAGE-A9在结直肠癌中的表达及临床意义
Expression of MAGE-A9 in colorectal cancer and its clinical significance
摘要
Abstract
Objective To observe the expression change of melanoma-associated antigen(MAGE)-A9 in colorectal cancer (CRC)tissue and to explore its significance.Methods The samples in 23 cases of initially diagnosed CRC in the Affiliated Hospital of Nantong University from January 2006 to December 2008 were collected.The quantitative real-time(qRT)-PCR was adopted to detect MAGE-A9 mRNA expression in cancer tissue and corresponding paracancerous tissue.Its correlation with the clinicopatho-logical features and prognosis was analyzed.Results The positive rate of MAGE-A9 in CRC tissue was significantly higher than that in paracancerous normal tissue(P<0.05).MAGE-A9 protein expression in CRC was related to the clinicopathological features such as tumor differentiation degree(P=0.011),TNM stage(P=0.003),tumor infiltration depth(P=0.001)and lymph node me-tastasis(P=0.003).The survival analysis showed that the expression of MAGE-A9 was closely related to the prognosis of CRC pa-tients.Conclusion MAGE-A9 expression is increased in CRC tissue,suggesting the poor prognosis.关键词
黑色素瘤相关抗原家族-A9/结直肠肿瘤/逆转录聚合酶链反应/免疫组织化学/生存分析Key words
melanoma-associated antigen-A9/colorectal neoplasma/reverse transcriptase polymerase chain reaction/immuno-histochemistry/survival analysis分类
医药卫生引用本文复制引用
陈建平,陈茜,施秀英,关茜,孔俊,张曙,朱慧君,王旭东..MAGE-A9在结直肠癌中的表达及临床意义[J].重庆医学,2018,47(9):1200-1203,4.基金项目
南通市科技计划资助项目(M S22015055). （M S22015055）
