南方医科大学学报2018，Vol.38Issue(3)：305-311,7.DOI:10.3969/j.issn.1673-4254.2018.03.10
脑铁沉积的MR定量分析方法:定量磁化率成像与横向弛豫率成像比较
Quantitative magnetic resonance imaging of brain iron deposition: comparison between quantitative susceptibility mapping and transverse relaxation rate(R2*)mapping
摘要
Abstract
Objective To evaluate the accuracy and sensitivity of quantitative susceptibility mapping (QSM) and transverse relaxation rate (R2*) mapping in the measurement of brain iron deposition. Methods Super paramagnetic iron oxide (SPIO) phantoms and mouse models of Parkinson's disease(PD)related to iron deposition in the substantia nigra(SN)underwent 7.0 T magnetic resonance (MR) scans (Bruker, 70/16) with a multi-echo 3D gradient echo sequence, and the acquired data were processed to obtain QSM and R2*.Linear regression analysis was performed for susceptibility and R2*in the SPIO phantoms containing 5 SPIO concentrations(30,15,7.5,3.75 and 1.875 μg/mL)to evaluate the accuracy of QSM and R2*in quantitative iron analysis.The sensitivities of QSM and R2*mapping in quantitative detection of brain iron deposition were assessed using mouse models of PD induced by 1-methyl-4-phenyl-1,2,3,6-tetrahy-dropyridine(MPTP)in comparison with the control mice. Results In SPIO phantoms,QSM provided a higher accuracy than R2*mapping and their goodness-of-fit coefficients(R2)were 0.98 and 0.89,respectively.In the mouse models of PD and control mice,the susceptibility of the SN was significantly higher in the PD models(5.19 ± 1.58 vs 2.98 ± 0.88,n=5;P<0.05),while the R2*values were similar between the two groups(20.22 ± 0.94 vs 19.74±1.75;P=0.60).Conclusion QSM allows more accurate and sensitive detection of brain iron deposition than R2*,and the susceptibility derived by QSM can be a potentially useful biomarker for studying PD.关键词
脑铁沉积/帕金森/磁共振成像/定量磁化率成像/横向弛豫率成像Key words
brain iron deposition/Parkinson's disease/magnetic resonance imaging/quantitative susceptibility mapping/transverse relaxation rate mapping引用本文复制引用
关基景,冯衍秋..脑铁沉积的MR定量分析方法:定量磁化率成像与横向弛豫率成像比较[J].南方医科大学学报,2018,38(3):305-311,7.基金项目
国家自然科学基金(61671228) Supported by National Natural Science Foundation of China(61671228). （61671228）
