南方医科大学学报2018，Vol.38Issue(3)：318-323,6.DOI:10.3969/j.issn.1673-4254.2018.03.12
微创和开放食管癌切除术对食管癌患者循环肿瘤细胞的影响
Effects of minimally invasive versus open esophagectomy on circulating tumor cells in patients with esophageal cancer
摘要
Abstract
Objective To investigate the effects of minimally invasive esophagectomy(MIE)and open esophagectomy(OE)on the level of circulating tumor cells (CTCs) in patients with esophageal cancer (EC). Methods A total of 73 patients with EC undergoing MIE (n=38) or OE (n=35) in our department between October, 2015 and October, 2017 were enrolled, with 10 patients with benign esophagus disease and 10 healthy volunteers as controls.The levels of CTCs in the peripheral blood of the participants were detected using CanPatrolTMtechnique and analyzed for their association with the operation methods and perioperative complications.Results CTCs were detected in 60.3%(44/73)of the EC patients but in none of the control subjects. CTC level after the surgery was significantly higher than that during the surgery, and CTC level during the surgery was significantly higher than that before surgery(P<0.001).The preoperative and intra-operative CTC levels were not significantly different between MIE and OE groups(P>0.05),but the postoperative CTC level was significantly lower in MIE group than in OE group,and postoperative increment of CTC level(from the preoperative level)was significantly lower in MIE group than in OE group (P<0.001). The total incidence of postoperative complications was significantly lower in MIE group than in OE group(28.9% vs 54.3%,P=0.023),and in both groups,CTC levels in patients with complications were significantly higher than those in patients without complications(P=0.001 and P=0.005 in MIE and OE groups,respectively).Conclusion MIE may help to reduce the number of peripheral blood CTCs early after the operation, and dynamic monitoring CTCs level assists in evaluation of the prognosis of EC patients.CTC level may serve as an indicator for monitoring the prognosis of EC.关键词
食管癌/食管癌切除术/循环肿瘤细胞/CanPatrolTMKey words
esophageal cancer/esophagectomy/circulating tumor cells/CanPatrolTM引用本文复制引用
郭鑫,吴源周,贾龙飞,李雅玲,闫玉生,陈群清..微创和开放食管癌切除术对食管癌患者循环肿瘤细胞的影响[J].南方医科大学学报,2018,38(3):318-323,6.基金项目
广东省科技计划项目(2016ZC0085) （2016ZC0085）
