南方医科大学学报2018，Vol.38Issue(3)：329-333,5.DOI:10.3969/j.issn.1673-4254.2018.03.14
潜在非小细胞肺癌标记物CHCHD2的表达及临床意义
Value of CHCHD2 as a potential marker of non-small cell lung cancer:analysis of 60 cases
摘要
Abstract
Objective To investigate the expression of CHCHD2,a potential tumor marker,in tumor and adjacent tissues from patients with non-small cell lung cancer (NSCLC). Methods Immunohistochemistry was used to detect the expression and location of CHCHD2 in the tumor tissues from 60 patients with NSCLC and 35 adjacent tissues to analyze the correlation of CHCHD2 expression with the clinicopathological variables and overall survival of the patients. The expression profile of CHCHD2 mRNA in NSCLC was analyzed using Oncomine database.Results The positivity rate of CHCHD2 was significantly higher in the tumor tissues than in adjacent tissues in patients with NSCLC(75.0% vs 17.1%).CHCHD2 positivity in the tumor tissues was associated with lymph node metastasis, pathological TNM stage, and tumor grades but not with age, gender, or histological type of the tumors. Analysis using Oncomine database showed that CHCHD2 mRNA was expressed at significantly higher levels in NSCLC than in normal control group (P<0.05). Kaplan-Meier survival analysis showed that NSCLC patients with a positive expression of CHCHD2 had a significantly shorter overall survival time than those negative for CHCHD2(P<0.05).Conclusion As a potential tumor marker,CHCHD2 over-expression plays a role in the occurrence and progression of NSCLC and promotes tumor invasion and metastasis, and can potentially serve as an indicator for early diagnosis and prognostic evaluation of NSCLC.关键词
非小细胞肺癌/CHCHD2/免疫组织化学/预后Key words
non-small cell lung cancer/CHCHD2/immunohistochemistry/prognosis引用本文复制引用
徐锐,王胜昱,王莉,李满祥,姚杨..潜在非小细胞肺癌标记物CHCHD2的表达及临床意义[J].南方医科大学学报,2018,38(3):329-333,5.基金项目
陕西省重点研发计划项目(2017SF-336) （2017SF-336）
