南方医科大学学报2018，Vol.38Issue(3)：353-357,5.DOI:10.3969/j.issn.1673-4254.2018.03.18
染色体微阵列分析方法诊断侧脑室增宽胎儿的临床价值
Clinical value of genome-wide chromosome microarray technique in diagnosis of fetal cerebral ventriculomegaly
摘要
Abstract
Objective To investigate the clinical value of gnome-wide chromosome microarray (CMA) technique in genetic etiological diagnosis of fetal cerebral ventriculomegaly.Methods A retrospective analysis was conducted in 109 women with singleton pregnancy, who were admitted in Nanfang Hospital with the diagnosis of cerebral ventriculomegaly in the fetuses by ultrasound between January, 2014 and December, 2016. Routine karyotype analysis and chromosome microarray analysis were performed to identify the chromosomal abnormalities in the fetuses.Results Karyotype analysis detected chromosomal abnormalities at a rate of 12.84% in these fetuses,significantly lower than the rate of 26.60% with CMA technique(P=0.004);the combined detection rate of the two techniques was 28.44%.In 17 cases,karyotype analysis yielded normal results while CMA microarray showed abnormalities with an extra abnormal detection rate of 15.60%.Among the 17 fetuses with chromosomal abnormalities, 6 had micro-deletion, 9 had micro-duplication, 1 had both micro-deletion and micro-duplication, and 1 had heterozygous loss of single parent diploid. Conclusion CMA technique can be used to detect abnormal chromosomal copy numbers in fetuses with cerebral ventriculomegaly to increase the detection rate of chromosomal abnormalities and facilitate prenatal consultation and prognostic evaluation.关键词
染色体微阵列分析/染色体核型分析/侧脑室增宽/临床价值Key words
chromosomal microarray analysis/karyotype analysis/cerebral ventriculomegaly/chromosomal abnormalities引用本文复制引用
彭奕贤,裘毓雯,常清贤,余艳红,钟梅,李堃芮..染色体微阵列分析方法诊断侧脑室增宽胎儿的临床价值[J].南方医科大学学报,2018,38(3):353-357,5.基金项目
广州市科技计划项目(2014Y2-00115) （2014Y2-00115）
