南方医科大学学报2018，Vol.38Issue(3)：358-362,5.DOI:10.3969/j.issn.1673-4254.2018.03.19
0.9ms 1064nm Nd:YAG激光联合伊曲康唑治疗趾甲真菌病
Effect of 0.9-ms 1064-nm Nd:YAG laser combined with itraconazole for treatment of toenail onychomycosis
摘要
Abstract
Objective To evaluate the efficacy and safety of 0.9-ms 1064-nm Nd:YAG laser alone or combined with itraconazole for treatment of toenail onychomycosis. Methods A total of 37 patients with onychomycosis (178 toenails) were randomly assigned to groups A and B, and each group was further divided into different subgroups according to the Scoring Clinical Index of Onychomycosis (SCIO) and Onychomycosis Severity Index (OSI) scoring.All the patients were treated with 0.9-ms Nd:YAG laser once a week for 8 times. The patients in group A were treated with laser alone, and those in group B were treated with laser combined with itraconazole. The clinical effect, clinical scores, appearance of the toenails and adverse reactions in the two groups were analyzed, and the patients'satisfaction rate was also investigated. Results At the 12th months of follow-up, the clinical response rate and mycological cure rate in group A were 31.33% and 30.00%, respectively, similar to the rates in group B (35.79% and 41.18%, respectively) (P>0.05). After the treatments, the SCIO and OSI scores showed no significant changes in group A(P>0.05)but both increased significantly in group B(P<0.05).The response rates did not differ significantly among the subgroups with SCIO<12 or with OSI<16(P>0.05),but showed significant differences among the subgroups with SCIO≥12 or with OSI≥16(P<0.05).Of the total of 178 toenails,33.71%,74.72% and 70.79% toenails showed improvements in terms of clear nail growth,shape and color,respectively.The overall patients'satisfaction rate was 62.16%, and no adverse reactions related with the therapy were recorded in these patients. Conclusion For treatment of toenail onychomycosis, 0.9-ms 1064-nm Nd:YAG laser can effectively improve the aesthetic appearance of the toenails, and a combined treatment with Nd:YAG laser and itraconazole can be better option in severe cases of onychomycosis.关键词
趾甲/甲真菌病/激光治疗/伊曲康唑Key words
toenails/onychomycosis/laser therapy/itraconazole引用本文复制引用
钟泽敏,胡燕卿,卢艳,周冼苡,杨烨玫,周思彤,胡永轩,毛祖豪,吴中,韩雪,刘康兴,黄诗韵..0.9ms 1064nm Nd:YAG激光联合伊曲康唑治疗趾甲真菌病[J].南方医科大学学报,2018,38(3):358-362,5.基金项目
天河区科技计划项目(2013KW008) （2013KW008）
