中国耳鼻咽喉头颈外科2017，Vol.24Issue(9)：456-460,5.DOI:10.16066/j.1672-7002.2017.09.005
听神经瘤临床特征与细胞免疫的相关性研究
Relationship between clinical characters of acoustic neuroma and cellular immunity
摘要
Abstract
OBJECTIVE To explore the relationship between the clinical characteristics of acoustic neuroma and the number ofT lymphocytes in tumor tissues.METHODS Clinical data of 65 patients diagnosed with VS were retrospectively collected.Peripheral blood samples of the patients were collected and the number of T lymphocytes were counted by flow cytometry.Immunohistochemistry was carried out with the fresh tumor samples compared with 8 normal cranial nerve controls.The expression level of each immune protein was analyzed its correlation with clinical characters was explored.RESULTS The CD3+,CD4+ and CD8+ T lymphocytes in the peripheral blood are not significantly correlated with clinical data.In the tumor tissues,the number of CD4+ and CD8+ T lymphocytes are much larger than those in normal cranial nerves,and negatively correlated with preoperative hearing.The number of CD8+ T lymphocytes has a negative relationship with postoperative facial nerve function.In addition,CD4 and CD8 expression levels in the tumor samples from patients younger than 40 are much higher than those in elder patients.Foxp3 is not detected in the normal cranial nerves.The number of Foxp3+ T lymphocytes is negatively correlated with preoperative hearing.CONCLUSION The CD4+ and CD8+ T lymphocytes mediated cellular immunity play an important role in the development of acoustic neuroma,as well as the reservation and restoration of nerve function.关键词
神经瘤,听/免疫,细胞/听阈/面神经/发病年龄Key words
Neuroma, Acoustic/Immunity, Cellular/Auditory Threshold/Facial Nerve/Age of Onset引用本文复制引用
火子榕,张治华,黄琦,汪照炎,贾欢,严爽,吴皓..听神经瘤临床特征与细胞免疫的相关性研究[J].中国耳鼻咽喉头颈外科,2017,24(9):456-460,5.基金项目
国家自然科学基金面上项目(81470681、81670919、81570906、81371086),国家自然科学基金青年项目(81700900)和上海申康医院发展中心新兴前沿技术项目(SHDC12013109)联合资助 （81470681、81670919、81570906、81371086）
