中国耳鼻咽喉头颈外科2017，Vol.24Issue(11)：565-568,4.DOI:10.16066/j.1672-7002.2017.11.004
紧密连接蛋白-1在下咽鳞状细胞癌组织中的表达及临床意义
Expression and its clinical significance of zonula occluden-1 in hypopharyngeal squamous cell carcinoma
周书芳 1汪旭 1吴昊 2达鹏 2马花瓷 2陈庆文 2张曙3
作者信息
- 1. 南通大学附属海安医院耳鼻咽喉科,江苏海安226600
- 2. 南通大学附属医院耳鼻咽喉科,江苏南通226001
- 3. 南通大学附属医院病理科,江苏南通226001
- 折叠
摘要
Abstract
OBJECTIVE To investigate the expression of zonula occluden-1(ZO-1) in hypopharyngeal squamous cell carcinoma(HSCC) and its clinical significance.METHODS Immunohistochemistry with tissue microarrays was used to detect the expression of the ZO-1 protein in 52 cases of HSCC.The correlation of prognosis and clinicopathological features was analyzed.RESULTS The expression of ZO-1 protein in HSCC was lower than that in adjacent tissues,its expression was closely related with tumor differentiation,tumor stage,tumor location and lymphatic metastasis.The Log-rank univariate analysis showed that the prognosis of HSCC was related to tumor differentiation,tumor stage,lymphatic metastasis and tumor location.The patients with lower expression of ZO-1 showed the worse prognosis than patients with higher expression of ZO-1.As shown in the Cox regression analyses,tumor differentiation,lymphatic metastasis,the ZO-1 expression and tumor stage were all independent prognostic factors.CONCLUSION The ZO-1 can serve as an independent prognostic factor of HSCC,and the low expression of ZO-1 is closely related to poor prognosis.关键词
下咽肿瘤/免疫组织化学/预后/紧密连接蛋白-1Key words
Hypopharyngeal Neoplasms/Immunohistochemistry/Prognosis/ZO-1引用本文复制引用
周书芳,汪旭,吴昊,达鹏,马花瓷,陈庆文,张曙..紧密连接蛋白-1在下咽鳞状细胞癌组织中的表达及临床意义[J].中国耳鼻咽喉头颈外科,2017,24(11):565-568,4.
