法医学杂志2018，Vol.34Issue(1)：60-66,7.DOI:10.3969/j.issn.1004-5619.2018.01.012
冠状动脉痉挛发病机制的研究进展及法医学应用
Research Progress and Forensic Application on the Pathogenesis of Coronary Artery Spasm
摘要
Abstract
Coronary artery spasm(CAS)is a hyper-contraction of segmental coronary artery in response to multiple stimuli. At present, it's still in lack of specific diagnostic indicators of sudden cardiac death caused by CAS. This review summarizes current researches on the mechanisms of CAS and describes the roles of vascular endothelial dysfunction and vascular smooth muscle hypersensitivity in the course of CAS. Furthermore, the molecular mechanisms of the endogenous NO and endothelin-1 cause vascular endothelial dysfunction, and the phosphorylation of MLC2, Rho kinase and endoplasmic reticulum stress related to vascular smooth muscle hypersensitivity are discussed. Meanwhile, the possibility of forensic application for the related molecules on the diagnosis of sudden cardiac death caused by CAS are also explored.关键词
法医病理学/冠状血管痉挛/综述/冠状动脉疾病/一氧化氮/内皮素-1/Rho相关激酶类/肌球蛋白轻链Key words
forensic pathology/coronary vasospasm/review/coronary artery disease/nitric oxide/endothe-lin-1/Rho-associated kinases/myosin light chain分类
社会科学引用本文复制引用
阙春杏,虞逸静,陈晗,史程,薛爱民..冠状动脉痉挛发病机制的研究进展及法医学应用[J].法医学杂志,2018,34(1):60-66,7.基金项目
上海市现场物证重点实验室开放课题基金资助项目(2014XCWZK13) （2014XCWZK13）
复旦大学基础医学院"正谊学者"基金资助项目(S18-14) （S18-14）
