国际病理科学与临床杂志2017，Vol.37Issue(11)：2345-2351,7.DOI:10.3978/j.issn.2095-6959.2017.11.010
CHCHD2在非小细胞肺癌中的表达及临床意义
Expression and clinical significance of CHCHD2 in non-small cell lung cancer patients
杨锋 1夏靖华 1孙盈 1王雪娇 1文苗苗 1李小飞 1张志培1
作者信息
- 1. 第四军医大学唐都医院胸腔外科,西安710038
- 折叠
摘要
Abstract
Objective:To detect the expression of CHCHD2 in non-small cell lung cancer (NSCLC) and normal tissues,and investigate its role and clinical significance on the process of NSCLC.Methods:The expression of CHCHD2 in NSCLC tissues and paired normal tissues of 209 cases was detected by immunohistochemistry method.The difference of CHCHD2 expression in clinicopathological parameters were analyzed by statistics.Results:Positive staining of CHCHD2 was mainly in cytoplasm.The positive expression rates of the CHCHD2 protein in NSCLC tissues was significantly higher than that in normal tissues (P＜0.001).In SCCs,no significant difference was found that CHCHD2 expression among different subtypes (P=0.957).However,in ADCs there were significant difference of CHCHD2 expression in different subtypes (P=0.027).The expression of CHCHD2 was significant difference among groups of pathological grading groups of SSCs and ADCs (P=0.009,P=0.006).There were significant difference of the CHCHD2 expression among various groups of T and N clinical stages (P=0.011,P＜0.001).Conclusion:CHCHD2 is over-expressed in NSCLC and differentially expressed proteins between NSCLC tissues and normal tissues.CHCHD2 over-expressed in NSCLC,might promote the development,invasion and metastasis of NSCLC,which is expected to be a prognostic indicator for NSCLC.关键词
非小细胞肺癌/CHCHD2/免疫组织化学Key words
non-small lung cancer/CHCHD2/immunohistochemistry引用本文复制引用
杨锋,夏靖华,孙盈,王雪娇,文苗苗,李小飞,张志培..CHCHD2在非小细胞肺癌中的表达及临床意义[J].国际病理科学与临床杂志,2017,37(11):2345-2351,7.
