临床与病理杂志2017，Vol.37Issue(11)：2363-2372,10.DOI:10.3978/j.issn.2095-6959.2017.11.013
前列腺全器官病理切片与前列腺多参数磁共振图像精准匹配的方法探究
Exploration of more accurate methods in matching whole-mount histopathology of prostates to multi-parameters of magnetic resonance images
摘要
Abstract
Objective:To analyze and compare the advantages and disadvantages of the routine method and the modified methods in matching the image of multi-parameters MRI (mpMRI) to whole-mount histopathology of prostate precisely.Methods:We collected 48 patients who undergone prostatectomy and conducted 3.0T mpMRI before the surgery between February 2017 and May 2017.The patients were divided into two groups:a control group used routine method to take tissue sample,and an experimental group used modified method.And then we matched the whole-mount histopathology with the MRI images by the two methods respectively.We compared the difference of results.Finally,we evaluated the accuracy of the two methods through the similarity between the paired images of pathology and MRI.Results:We obtained 176+24 (apex) tissue blocks by the routine method but 198+24(apex) ones were obtained by the modified method.Furthermore,tissue blocks obtained by the modified method was thinner and more homogeneous [(2.98 ±0.247) mm vs (3.64±0.49) mm,P＜0.0001] for average thickness than by the routine method.The gradient of section obtained by modified method was smaller than routine method in coronal and sagittal view.Compared with the routine method,there were 92 pathology sections which are matched to different mpMRI images by two different methods of all 374 whole-mount histopathology.The final matching scores of the two methods were 3.250 vs 4.129 (P＜0.001).Conclusion:The modified method has significantly advantages in matching hispathology section to mpMRI images.We can improve the alignment after introduced modified method into the future work.关键词
前列腺癌/前列腺全器官切片/多参数磁共振/取材器/图像匹配Key words
prostatic cancer/whole-mount histopathology/multiple parameter magnetic resonance image/draw material device/match引用本文复制引用
吕晓宇,张青,付尧,李铭,曹文敏,江波,陆加明,刘光香,郭宏骞..前列腺全器官病理切片与前列腺多参数磁共振图像精准匹配的方法探究[J].临床与病理杂志,2017,37(11):2363-2372,10.基金项目
南京市科技发展计划项目(201605013).This work was supported by Municipal Science and Technology Development Project Foundation of Nanjing,China (201605013). （201605013）
