临床与病理杂志2017，Vol.37Issue(11)：2395-2401,7.DOI:10.3978/j.issn.2095-6959.2017.11.018
血MUC1 mRNA和cyfra21-1蛋白对非小细胞肺癌的诊断价值
Value of peripheral blood MUC1 mRNA and cyfra21-Ⅰ in diagnosis of non-small cell lung carcinoma
摘要
Abstract
Objective:To investigate the value of peripheral blood Mucin 1 (MUC1) mRNA and cytokeratin 19 fragment (cyfra21-1) in diagnosis of non-small cell lung carcinoma (NSCLC).Methods:Eighty patients with NSCLC (NSCLC group),50 patients with benign pulmonary disease (benign group) and 40 healthy cases (healthy group) were enrolled in this study.The levels ofMUC1 mRNA and cyfra21-1 were detected.The values ofMUC1 mRNA and cyfra21-1 in diagnosis of NSCLC were analyzed.The differences ofMUC1 mRNA and cyfra21-1 positive rate were compared in patients with different pathological features.Results:The levels ofMUC1 mRNA and cyfra21-1 in NSCLC group were significantly higher than those in the benign group and the healthy group (P＜0.05);while there was no significant difference in levels of MUC1 mRNA and cyfra21-1 between the benign group and the healthy group (P＞0.05).The best cut-offvalue ofMUC1 mRNA in diagnosis of NSCLC was MUC1 mRNA ＞2.14 with the sensitivity was 68.8％ and specificity was 94.4％.The best cut-offvalue of cyfra21-1 was cyfra21-1 ＞3.20 ng/mL with the sensitivity was 75.0％ and specificity was 98.9％.The sensitivity ofjoint application ofMUC1 mRNA and cyfra21-1 was 87.5％,which was significantly higher than that ofMUC1 mRNA or cyfra21-1 alone (P＜0.05),while there was no significant difference in specificity (P＞0.05).The positive rates ofMUC1 mRNA and cyfra21-1 were significantly correlated with tumor size,differentiated degree,TNM staging,and lymph node metastasis (P＜0.05),but no correlated with age,gender and histologic type (P＞0.05).Conclusion:The detections ofMUC1 mRNA and cyfra21-1 are helpful in clinical diagnosis and disease evaluation of NSCLC.关键词
黏蛋白1/细胞角蛋白19片段/非小细胞肺癌Key words
Mucin 1/cyfra21-1/non-small cell lung carcinoma引用本文复制引用
蒋平平,李冬,杨凡..血MUC1 mRNA和cyfra21-1蛋白对非小细胞肺癌的诊断价值[J].临床与病理杂志,2017,37(11):2395-2401,7.基金项目
国家自然科学基金(81472179) （81472179）
上海市加强公共卫生体系建设3年行动计划(2015～2017年)(15GWZK0301).This work was supported by National Natural Science Foundation (81472179) and Three-year Planning for Strengthening the Construction of Public Health System in Shanghai(2015-2017)(15GWZK0301),China. （2015～2017年）
