临床与病理杂志2017，Vol.37Issue(11)：2407-2415,9.DOI:10.3978/j.issn.2095-6959.2017.11.020
肝动脉化疗栓塞术对原发性肝癌患者肝肾功能及血常规的影响
Effect of transcatheter arterial chemoembolization on liver and kidney function and blood routine in patients with primary liver cancer
摘要
Abstract
Objective:To investigate the effect of transcatheter arterial chemoembolization (TACE) on liver and kidney function and blood routine in patients with primary liver cancer.Methods:Clinical data of 57 patients with primary hepatocellular carcinoma treated with TACE were collected.The differences of liver and kidney function and blood routine indexes were compared between the same patients before and after operation.And the related factors of liver function injury after TACE were analyzed.Results:The levels of alanine aminotransferase and aspartate aminotransferase were significantly increased at the Ist day after TACE treatment.Serum total protein (TP) and serum albumin (ALB) decreased gradually from the 1st day to the 1st week after operation.Total bilirubin and direct bilirubin (DBil) were higher on the third day after operation than on the 1st and 7th day.Differences were statistically significant (P＜0.05).The white blood cell count was significantly increased on the 1st day after operation and the difference was statistically significant (P＜0.05).There were significant correlations between liver function injury after TACE and preoperative white blood cell count,platelet count,preoperative total protein,preoperative albumin,preoperative total bilirubin,preoperative liver function Child-Pugh grade and portal vein thrombosis (P＜0.05).Conclusion:TACE can cause liver injury,transient impairment of renal function and a transient increase in white blood cell count in patients with primary liver cancer.Primary liver cancer patients who have low preoperative white blood cell count and platelet count,low preoperative total protein and preoperative albumin,high preoperative total bilirubin and whose preoperative liver function Child-Pugh grade is B grade and who is combined with portal vein tumor thrombus are more likely to occur liver injury after TACE.关键词
原发性肝癌/肝动脉化疗栓塞术/肝功能Key words
primary liver cancer/transcatheter arterial chemoembolization/liver function引用本文复制引用
周宇杰,徐细明,梁慧玲,陈嘉羽..肝动脉化疗栓塞术对原发性肝癌患者肝肾功能及血常规的影响[J].临床与病理杂志,2017,37(11):2407-2415,9.基金项目
湖北省自然科学基金(2012FKC14301).This work was supported by Hubei Provincial Natural Science Foundation,China(2012FKC14301). （2012FKC14301）
