临床与病理杂志2017，Vol.37Issue(11)：2479-2484,6.DOI:10.3978/j.issn.2095-6959.2017.11.032
前列腺癌中TMPRSS2-ERG融合基因作用机制的研究进展
Research progress in the mechanism of TMPRSS2-ERG fusion gene in prostate cancer
丘佳明1
作者信息
- 1. 常熟市第二人民医院病理科,江苏常熟215500
- 折叠
摘要
Abstract
Prostate cancer is the most common malignancy in European and American male.In China,the morbidity,mortality,and the burden of disease are increasing obviously.But the mechanism of prostate cancer is still not clear.The fusion of transmembrane serine protease 2 (TMPRSS2) and the E26 oncogene (ERG) has prostate cancer specific,it plays an important role in the genesis and development of prostate cancer.The mechanism of action is complex,and interacts with multiple genes.Therefore,an understanding of the mechanism of TMPRSS2-ERG fusion gene in prostate cancer is essential,which can help prostate cancer diagnosis and treatment.关键词
TMPRSS2-ERG融合基因/前列腺癌/雄激素受体/磷酸酶与张力蛋白同源蛋白/斑点型锌指结构蛋白Key words
TMPRSS2-ERG fusion gene/prostate cancer/androgen receptor/phosphatase and tensin homology deleted on chromosome ten/speckle-type POZ protein引用本文复制引用
丘佳明..前列腺癌中TMPRSS2-ERG融合基因作用机制的研究进展[J].临床与病理杂志,2017,37(11):2479-2484,6.
