国际病理科学与临床杂志2017，Vol.37Issue(12)：2571-2575,5.DOI:10.3978/j.issn.2095-6959.2017.12.010
绝经后2型糖尿病患者骨转换标志物与糖化血红蛋白水平的相关性
Correlation of bone turnover markers and glycosylated hemoglobin in postmenopausal women with type 2 diabetes mellitus
摘要
Abstract
Objective:To analyze the correlation of bone turnover markers (BTMs) and glycosylated hemoglobin (HbAlc) in postmenopausal women with type 2 diabetes mellitus (T2DM).Methods:A total of 59 postmenopausal women with T2DM were divided into group A (HbAlc＜9.0％,n=32) and group B (HbAlc≥9.0％,n=27) according to glycosylated hemoglobin level.The differences of procollagen Ⅰ N-terminal peptide (PINP) and type 1 collagen protein C-terminal crosslinking peptide (CTX) between the two groups were compared,and the correlation analysis of bone turnover markers was carried out.Results:PINP and CTX in group A were lower than those in group B,the difference was statistically significant (P=0.022,0.020).Correlation analysis showed that PINP was negatively correlated with HbA1 c (r=-0.435,P=0.001).CTX was negatively correlated with TC (r=-0.321,P=0.013),positively correlated with 25 hydroxyvitamin D (25-OHD) (r=0.278,P=0.033),and negatively correlated with HbA1c (r=-0.390,P=0.002).Multivariate stepwise regression analysis showed that PINP and CTX were all affected by HbA1c.Conclusion:With the increase of HbA1c level,postmenopausal women with T2DM decreased bone formation and bone absorption,and decreased overall bone turnover.By actively controlling blood glucose,it helps maintain bone turnover balance and improves bone quality,thereby reducing the risk of fracture.关键词
2型糖尿病/绝经后/糖化血红蛋白/骨转换标志物Key words
type 2 diabetes mellitus/postmenopausal/glycosylated hemoglobin/bone turnover markers引用本文复制引用
张强,王国娟,司玮,孙春萍,刘皆,胡国平,吕芳,马维青..绝经后2型糖尿病患者骨转换标志物与糖化血红蛋白水平的相关性[J].国际病理科学与临床杂志,2017,37(12):2571-2575,5.基金项目
安徽省公益性研究联动计划(1501ld04065). This work was supported by Anhui Provincial Public Welfare Research Linkage Plan,China (1501ld04065). （1501ld04065）
