临床与病理杂志2017，Vol.37Issue(12)：2605-2610,6.DOI:10.3978/j.issn.2095-6959.2017.12.016
回生口服液联合一线化疗方案对晚期非小细胞肺癌患者血清VEGF,IL-6和MMP-9水平的影响
Effects of Huisheng oral liquid combined with first-line chemotherapy on serum levels of VEGF, IL-6 and MMP-9 in advanced non-small cell lung cancer patients
摘要
Abstract
Objective:To investigate the clinical effect of Huisheng oral liquid combined with first-line chemotherapy on serum levels of VEGF,IL-6 and MMP-9 in advanced non-small cell lung cancer patients.Methods:We selected 95 patients with advanced non-small cell lung cancer treated in our hospital from May 2011 to June 2014.According to different treatment methods,the patients were divided into two groups:observation group and control group.The observation group received Huisheng oral liquid combined with first-line chemotherapy,the control group just received first-line chemotherapy.After four courses of treatment,the short-term effect and the serum VEGF,IL-6,MMP-9 levels in two groups were compared.Results:The total effective rate of observation group was 72.92％,it is 53.19％ for control group,there had the significant difference in clinical efficacy between the two groups (PVEGF＜0.001,PIL-6=0.022,PMMP-9＜0.001).The serum VEGF,IL-6,MMP-9 levels of two groups were similar before treatment,there were no significant differences (PVEGF=0.072,PIL-6=0.054,PMMP-9=0.121).After the treatment,in disease control group,serum levels ofVEGF,IL-6,MMP-9 were significantly decreased (PVEGF＜0.001,PIL-6=0.016,PMMP-9＜0.001);and the observation group were lower than in the control group,the differences were statistically significant (PVEGF=0.003,PIL-6=0.011,PMMP-9=0.005).But in the disease progression group,the serum VEGF,IL-6,MMP-9 levels increased and the difference was statistically significant (PVEGF=0.003,PIL-6=0.027,PMMP-9=0.021).The main side effects of the two groups were digestive tract reaction and bone marrow suppression,and the incidence of WBC decrease in the observation group was significantly lower than that in the control group (P=0.013).Conclusion:The combine of Huisheng oral liquid and first-line chemotherapy can monitor the serum levels ofVEGF,IL-6 and MMP-9 in advanced non-small cell lung cancer patients.This method can achieve better results.关键词
非小细胞肺癌/回生口服液/血管内皮生长因子/白细胞介素-6/基质金属蛋白酶-9Key words
non-small cell lung cancer/Huisheng oral liquid/vascular endothelial growth factor/interleukin-6/matrix metalloproteinase-9引用本文复制引用
吴明君,王向东,陈瑜,杨林东,梁玉河..回生口服液联合一线化疗方案对晚期非小细胞肺癌患者血清VEGF,IL-6和MMP-9水平的影响[J].临床与病理杂志,2017,37(12):2605-2610,6.基金项目
国家自然科学基金青年项目(81602597). This work was supported by the Youth Project of National Natural Science Foundation,China (81602597). （81602597）
