临床与病理杂志2017，Vol.37Issue(12)：2705-2708,4.DOI:10.3978/j.issn.2095-6959.2017.12.032
紫草素抗白血病机制的研究进展
Research progress in the mechanism of anti-leukemia effects of shikonin
摘要
Abstract
Shikonin is one of the main active ingredients of Chinese traditional herb,Zicao,which has multiple biological functions of antitumor,anti-bacteria,anti-virus,and wound healing.Leukemia is the most common malignant disease of hematological system.A series of studies have already showed the anti-leukemia effects of shikonin.Based on current literatures,this review summarized the anti-leukemia effects ofshikonin and their mechanisms.The present review focused on the effects of proliferative inhibition and inducing apoptosis,necroptosis,and cell differentiation of shikonin on leukemia cells,and their molecular mechanisms,which may be beneficial for further study and clinical translation.关键词
紫草素/白血病/细胞凋亡/程序性坏死/细胞分化Key words
shikonin/leukemia/cell apoptosis/necroptosis/cell differentiation引用本文复制引用
陈一畅..紫草素抗白血病机制的研究进展[J].临床与病理杂志,2017,37(12):2705-2708,4.基金项目
吉林省卫生厅课题(2014Q030).This work was supported by the Health Commission of Jilin Province,China(2014Q030). （2014Q030）
