摘要
Abstract
Objective:To compare the effect of different dose recombinant tissue-type plasminogen activator (rt-PA) on acute pulmonary embolism (APE).Methods:105 APE patients treated in our hospital from January 2010 to May 2017 were selected and randomly divided into an observation group (n=53) and a control group (n=52).The patients in the observation group received 50 mg rt-PA,while those in the control group received 100 mg rt-PA.The clinical efficacy,right ventricular left and right diameter,main pulmonary diameter,pulmonary arterial systolic pressure,PaO2,arterial systolic pressure,D-dimer level and prognosis were compared.Resuits:The fight ventricular left and right diameter,main pulmonary diameter,pulmonary arterial systolic pressure and D-dimer level were decreased,while PaO2 and arterial systolic pressure were increased in both group at 60 min and 24 h post-treatment (P＜ 0.05),but the improvements at 60 min post-treatment in the control group were more significant compared with the observation group (P＜0.05).No significant differences were found between the two group after 24 h treatment with regard to above indexes (P＞ 0.05).The mortality and bleeding rate of the observation group were lower than those of the control group (P＜0.05).Conclusion:50 mg rt-PA had a similar efficacy with 100 mg rt-PA for APE,and lower mortality and bleeding rate.High dose rt-PA was more speedy.关键词
急性肺栓塞/重组组织型纤溶酶原激活剂/溶栓治疗Key words
acute pulmonary embolism/recombinant tissue-type plasminogen activator/thrombolytic therapy分类
医药卫生
