广西医学2017，Vol.39Issue(12)：1773-1776,4.DOI:10.11675/j.issn.0253-4304.2017.12.02
结缔组织病相关肺间质病变患者血清和支气管肺泡灌洗液生物学标志物的表达及其临床意义
Expression and clinical significance of biomarkers in serum and bronchoalveolar lavage fluid from patients with connective tissue disease-associated interstitial lung disease
摘要
Abstract
Objective To investigate the expression level and clinical significance of Krebs von den Lungen-6 (KL-6),monocyte chemotactic protein 1 (MCP-1),surfactant protein(SP)-A and SP-D in serum and bronchoalveolar lavage fluid (BALF) from patients with connective tissue disease-associated interstitial lung disease (CTD-ILD).Methods Sixty patients with connective tissue disease (CTD) were divided into CTD-ILD group(n =28) and CTD without interstitial lung disease (ILD) group (n =32).Twenty healthy persons were enrolled as control group.The KL-6,MCP-1,SP-A and SP-D levels were detected in serum and BALF from patients with CTD or in serum from patients in the control group.The correlations of KL-6,MCP-1,SP-A and SP-D levels in serum and BALF with forced vital capacity (FVC),diffusion capacity for carbon monoxide of lung(DLCO),or high-resolution CT score of the lung were analyzed among patients with CTD-ILD.Results The serum KL-6,MCP-1,SP-A and SP-D levels increased in the order of the control group,the CTD without ILD group and the CTD-ILD group(P ＜ 0.05).The BALF KL-6,MCP-1,SP-A and SP-D levels in the CTD-ILD group were higher than those in the CTD without ILD group(P ＜ 0.05).Among patients with CTD-ILD,the KL-6,MCP-1,SP-A and SP-D levels in serum and BALF negatively correlated with FVC and DLCO (all P ＜ 0.01),and positively correlated with high-resolution CT score of the lung(all P ＜ 0.05).Conclusion High expressions of KL-6,MCP-1,SP-A and SP-D are seen in serum and BALF from patients with CTD-ILD.The combined detection of the biomarkers above contributes to early diagnosis and severity evaluation of CTD-ILD.关键词
结缔组织病/肺间质病变/涎液化糖链抗原-6/单核细胞趋化蛋白-1/肺泡表面活性蛋白/血清/支气管肺泡灌洗液Key words
Connective tissue disease/Interstitial lung disease/Krebs von den Lungen-6/Monocyte chemotactic protein 1/Surfactant protein,Serum/Bronchoalveolar lavage fluid分类
医药卫生引用本文复制引用
张继云,穆清爽,赵旌,王梅,李文艳,齐晶..结缔组织病相关肺间质病变患者血清和支气管肺泡灌洗液生物学标志物的表达及其临床意义[J].广西医学,2017,39(12):1773-1776,4.基金项目
新疆维吾尔自治区自然科学基金(2015211C109) （2015211C109）
