广西医学2017，Vol.39Issue(12)：1805-1807,3.DOI:10.11675/j.issn.0253-4304.2017.12.11
逆向优化算法在宫颈癌三维近距离放疗计划制定中的应用
Application of inverse planning simulated annealing to fomulating three-dimensional radiobrachytherapy plans for cervical cancer
摘要
Abstract
Objective To investigate the value of inverse planning simulated annealing(IPSA) applied to the three-dimensional radiobrachytherapy plans for cervical cancer.Methods Two IPSA plans (IPSA1 and IPSA2) and forward graphical optimization (GRO) plan were made based on the CT images of 60 cervical cancer patients.A parameter,maximum volume dose,was added in IPSA2 plan compared to IPSA1 plan.The influences of the three plans and different optimized parameters on dosimetry were analyzed.Results Compared to GRO plan,IPSA1 plan increased the target coverage(D90,D100) and target dose of V100 (P ＜0.05).There were no significant differences in the target dose(V150 or V200) between IPSA1 and GRO plans(P ＞ 0.05).Compared to IPSA1 plan,IPSA2 plan decreased V100,V150,V200,D90,D100 and the dose for rectum(P ＜ 0.05).Among the three plans,the planning duration of IPSA1 plan was the least (P ＜ 0.05).Conclusion In the three-dimensional radiobrachytherapy plans for cervical cancer,IPSA can improve the dosimetric outcomes of forward planning,and decrease the duration for planning.IPSA can decrease the high dose for the target volume by restricting the maximum surface dose,but the maximum volume dose may not be restricted.关键词
宫颈癌/逆向优化算法/拖拽优化/三维/近距离放射治疗/剂量学/放疗计划Key words
Cervical cancer/Inverse planning simulated annealing/Graphical optimization/Three dimension/Radiobrachytherapy/Dosimetry/Radiotherapy plan分类
医药卫生引用本文复制引用
刘志杰,朱小东,付庆国,杨海明,邓烨,罗庭军..逆向优化算法在宫颈癌三维近距离放疗计划制定中的应用[J].广西医学,2017,39(12):1805-1807,3.基金项目
广西医药卫生科研课题(Z2016481) （Z2016481）
广西医科大学青年科学基金(GXMUYSF201627) （GXMUYSF201627）
