河北医学2018，Vol.24Issue(3)：353-357,5.DOI:10.3969/j.issn.1006-6233.2018.03.001
HIF-1αGlut-1表达与乳腺癌分化程度及分子亚型的关系
The Relationship between the Expression of A and B and the Degree of Differentiation and Subtypes of Breast Cancer
摘要
Abstract
Objective:To investigate the relationship between the expression of -1 - alpha (HIF-1-α),glucose transporter 1(Glut-1) and the degree of differentiation and molecular subtypes of breast cancer. Methods:Immunohistochemical method was used to detect the expression of HIF-1α and Glut-1 in 102 ca-ses of breast cancer and 60 cases of adjacent normal tissues. The expression rates of HIF-1α and Glut-1 in breast cancer tissues with different degree of differentiation and molecular typing were compared. Results:The positive expression rates of HIF-1α and Glut-1 protein in breast cancer tissues were 62.75% and 68.63%, respectively,which were higher than those in 11.67% normal tissues. The difference was statistically signifi-cant (P < 0.05). The positive expression rates of HIF-1α and Glut-1 protein in high differentiated breast cancer tissues were 34.78% and 40.91%,respectively,which were lower than those of moderately differentia-ted 60%,68.88%,and poorly differentiated 85.29% and 88.24% (P < 0.025). The differentiation of moder-ately differentiated breast cancer was lower than that of poorly differentiated ones(P < 0.025). There was no significant difference in positive expression rates of HIF-1α and Glut-1 protein between Luminal A type breast caner and Luminal B type breast caner (46.67% and 51.11% vs 54.55% and 63.64%) (P > 0.017). However,the rates in Luminal A and Luminal B type breast cancer were all lower than those in tissues with o-ver-expressed HER-2(85.71%,92.86%) and triple negative breast cancer(90.48%and 95.24%) (P <0. 017). There was no significant difference between HER-2 overexpression type and three yin type (P > 0.017).Conclusion:The expression of HIF-1α and Glut-1 in breast cancer patients is highly positive,and the positive expression of HIF-1 alpha and Glut-1 in different degree of differentiation and molecular subtype of breast cancer is different.关键词
缺氧诱导因素-1α/葡萄糖转运蛋白1/乳腺癌/分子分级/分化程度Key words
Hypoxia inducible factor-1α/Glucose transporter 1/Breast cancer/Molecular classification/Differentiation degree引用本文复制引用
赵文明,周炳娟,李金梅,陈雪,张金库..HIF-1αGlut-1表达与乳腺癌分化程度及分子亚型的关系[J].河北医学,2018,24(3):353-357,5.基金项目
河北省保定市科学研究与发展计划项目,(编号:16ZF110) （编号:16ZF110）
