河北医学2018，Vol.24Issue(3)：362-365,4.DOI:10.3969/j.issn.1006-6233.2018.03.003
miR-381在食管癌组织中的表达及临床意义
Expression and Clinical Significance of miR-381 in Tissues of Esophageal Carcinoma
杨泽波 1张媛媛 1陶开义 1杨勇 1胡旭1
作者信息
- 1. 湖北省宜昌市中心人民医院胸心外科, 湖北 宜昌 443003
- 折叠
摘要
Abstract
Objective:To investigate the expression of miR-381 in tissues of esophageal cancer and its clinical significance. Methods:108 cases of esophageal cancer admitted to our hospital were selected as the research object,and the QRT-PCR method was used to detect the expression of miR-381 in postoperative cancer tissues and adjacent normal tissues.Analyzed the relationship between the expression of miR-381 and the clinicopathological features of esophageal cancer patients. Results:The expression of miR-381 in esopha-geal cancer tissues was significantly lower than that in adjacent normal tissues(0.47 ± 0.22 vs 1.02 ± 0.97), and the difference was statistically significant (P <0.05). The expression level of miR-381 in esophageal cancer was closely related to the TNM staging,differentiation degree,infiltration degree and lymph node me-tastasis (P <0.05),and the expression level of miR-381 in esophageal cancer tissues had no significant cor-relation with clinicopathological features such as gender,age,tumor diameter and tumor location(P> 0.05). Conclusions:MiR-381 in esophageal cancer is low expression, and its expression level is closely related to the occurrence and development of esophageal cancer,miR-381 may be a potential biomarker for the diagno-sis of esophageal cancer and a new therapeutic target.关键词
miR-381/食管癌/QRT-PCR/病理特征Key words
miR-381/Esophageal cancer/QRT-PCR/Pathological features引用本文复制引用
杨泽波,张媛媛,陶开义,杨勇,胡旭..miR-381在食管癌组织中的表达及临床意义[J].河北医学,2018,24(3):362-365,4.
