河北医学2018，Vol.24Issue(3)：469-473,5.DOI:10.3969/j.issn.1006-6233.2018.03.032
放射性125I粒子治疗胰腺癌患者的临床观察
Clinical Observation of Radioactive 125I Particles in the treatment of Pancreatic Cancer Patients
摘要
Abstract
Objective:To investigate the effect of radioactive 125I particles in pancreatic cancer patients. Methods:58 pancreatic cancer patients admitted n our hospital were selected and divided into the control group and the experiment group by order of medical treatment. The control group were treated by palliative op-eration and the experiment group were treated by CT guided radioactive 125I particles implantation. Two groups were both treated by conventional anti-inflammatory,analgesic,fluid replacement and other supporting symp-tomatic treatment after operation. The CEA, CA125, CA199, pain assessment, quality of life score, solid tumor curative effect and median survival time were compared before treatment and 1 month after treatment. Results:Compared with before treatment,the CEA,CA125 and CA199 level were lower(P<0.05),the ex-periment group were more obviously(P<0.05).Compared with before treatment,the VAS score were lower(P<0.05),the experiment group were more obviously (P<0.05). Compared with the control group after treat-ment the tumor curative effect were better(P<0.05),the median survival time were longer(P<0.05). Con-clusion:Radioactive 125I particles can significantly reduce serum CEA, CA125 and CA199 levels in patients with pancreatic cancer,effectively alleviate the pain,improve clinical symptoms,improve the quality of life of patients,the tumor tissue has good killing effect,can effectively prolong the relative survival time of patients.关键词
放射性125I粒子/胰腺癌/CEA/CA125/CA199Key words
Radioactive 125I particles/Pancreatic cancer/CEA/CA125/CA199引用本文复制引用
刘宪兴,梁静波,常番,史连盟,陈昂..放射性125I粒子治疗胰腺癌患者的临床观察[J].河北医学,2018,24(3):469-473,5.基金项目
青海省科学技术成果计划项目,(编号:9632016J0456) （编号:9632016J0456）
