河北医学2018，Vol.24Issue(3)：502-506,5.DOI:10.3969/j.issn.1006-6233.2018.03.042
整合素 α2β1蛋白和CD44V3蛋白在宫颈鳞癌的表达及意义
Expression and Significance of Integrin α2β1 Protein and CD44V3 Protein in Cervical Squamous cell Carcinoma
摘要
Abstract
Objective: To investigate the expression and clinical significance of integrin α2β1 protein and CD44V3 protein in cervical squamous cell carcinoma. Methods: Expression protein of integrinα2β1 and CD44V3 were detected in 80 cases of cervicals quamous cell carcinoma and normal cervical tissues 50 cases by SP method of immunohistochemistry. The correlation between the expression of two indexes in cervical squa-mous cell carcinoma and the relationship with the biological behavior of cervical squamous cell carcinoma were investigated. Result:The positive expression rates of integrin alpha 2 beta 1 protein and CD44V3 protein in cervical squamous cell carcinoma were 73.4% and 71.3%, respectively, which were all higher than those in normal cervical mucosa tissues, and the difference was statistically significant (P < 0.05). Integrin alpha 2 beta 1 protein and CD44V3 protein were significantly related to the degree of differentiation, clinical stage, lymph node metastasis and depth of invasion of cervical squamous cell carcinoma. The expression of integrin alpha 2 beta 1 protein and CD44V3 protein in the squamous cell carcinoma of the cervix was positively correla-ted (R =0.67). Conclusion:Expression of integrinα2β1 and CD44V3 protein may play an important role in the occurrence and development of cervical squamous cell carcinoma. They have positive synergy,and be used as a judgment of local invasion, distant metastasis and prognosis prediction factors of cervical squamous cell carcinoma.关键词
整合素α2β1/CD44V3/宫颈鳞癌/免疫组化Key words
Integrinα2β1/CD44V3/Cervical squamous cell carcinoma/Immunohistochemistry引用本文复制引用
赵耀红,祁志宇,郭东侠,刘淑娟,陈海荣,赵长祺..整合素 α2β1蛋白和CD44V3蛋白在宫颈鳞癌的表达及意义[J].河北医学,2018,24(3):502-506,5.基金项目
河北省承德市科技支撑计划项目,(编号:201601A003) （编号:201601A003）
河北省高等学校科学技术研究青年基金项目,(编号:QN2016141) （编号:QN2016141）
