河北医学2018，Vol.24Issue(3)：520-524,5.DOI:10.3969/j.issn.1006-6233.2018.03.047
维持性血液透析患者生化指标与心理功能的相关性及影响因素
Correlation and Influencing Factors of Biochemical iIndex and Psychological Function in Maintenance Hemodialysis Patients
摘要
Abstract
Objective:To explore the correlation of biochemical indexes and psychological function in maintenance hemodialysis patients, and to analyze the influencing factors. Methods: 58 patients undergoing maintenance hemodialysis (study group) in our hospital during the period from November 2015 to December 2016 and 30 healthy volunteers (healthy group) who received physical examination in our hospital during the same period were selected as the subjects. Patients in the study group were divided into the poor psychological function group and the good psychological functiongroup according to the psychological function in patients un-dergoing maintenance hemodialysis. The biochemical parameters hemoglobin(Hb),total protein(TP),albu-min (Alb),prealbumin(PA),serum creatinine(SCr),blood urea nitrogen(BUN),serum calcium(Ca), brain-derived neurotrophic factor (BDNF) and psychological function evaluated with the psychiatric symptom checklist (SCL-90) were compared between the two groups,and correlation analysis was performed. The in-dependent influencing factors of psychological function were analyzed by multiple Logistic regression analysis. Results:There were significant differences of Hb, Alb and BDNF among the three groups (P< 0.05), and there were significant differences of PA,SCr,BUN and Ca between the poor psychological function group and the healthy group(P< 0.05). There was a significant difference of BUN between the good psychological func-tion groupand the healthy group (P< 0.05), but there was no significant difference in TP among the three groups(P> 0.05).The SCL-90 score of poor psychological function group was higher than that of the good psychological function group and the healthy group, with significant differences between groups (P< 0.01). Hb,Alb and BDNF were independent factors influencing the psychological function in patients undergoing ma-intenance hemodialysis(P< 0.05). Conclusion: There are great differences in biochemical indexes and psy-chological functionbetween patients undergoing maintenance hemodialysisand healthy people. Hb, Alb and BDNF are important factors influencing the psychological function in patients undergoing maintenance hemodi-alysis,and relevant indicators should be monitored in clinical practice.关键词
维持性血液透析/生化指标/心理功能/相关性/影响因素Key words
Maintenance hemodialysis/Biochemical index/Psychological function/Correla-tion/Influencing factors引用本文复制引用
何俊..维持性血液透析患者生化指标与心理功能的相关性及影响因素[J].河北医学,2018,24(3):520-524,5.基金项目
湖北省卫生厅科研项目,(编号:13093654) （编号:13093654）
