郑州大学学报（医学版）2018，Vol.53Issue(1)：21-24,4.DOI:10.13705/j.issn.1671-6825.2016.12.060
食管鳞癌组织中GSK3β表达的临床意义
Clinical significance of GSK3β expression in esophageal squamous cell carcinoma tissue
摘要
Abstract
Aim:To characterize the expression level of GSK3β and its clinical significance in esophageal squamous cell carcinoma(ESCC) tissue.Methods:The mRNA and protein expression levels of GSK3β in 52 cases of ESCC and matched adjacent tissue samples were determined by Real-time PCR,Western blot and immunohistochemistry,respectively,and the correlation between the expression of GSK3 β and the prognosis of patients was also analyzed using Cox regression.Restults:The mRNA and protein expression levels,and the positive rate of GSK3β in ESCC tissue were higher compared with those in adjacent noncancerous mucosa tissue(P ＜ 0.05).Cox regression analysis showed that GSK3β was an independent risk factor for the prognosis of patients with ESCC (β =1.095,P =0.026).Conclusion:GSK3β expression may promote the development of ESCC,and GSK3β may be one of the molecular targets for treatment of ESCC.关键词
食管鳞癌/GSK3β/预后Key words
esophageal squamous cell carcinoma/GSK3β/prognosis分类
医药卫生引用本文复制引用
刘怡文,孙蔚,齐义军,高社干..食管鳞癌组织中GSK3β表达的临床意义[J].郑州大学学报（医学版）,2018,53(1):21-24,4.基金项目
国家自然科学基金资助项目(81472234) （81472234）
