郑州大学学报（医学版）2018，Vol.53Issue(2)：225-229,5.DOI:10.13705/j.issn.1671-6825.2017.06.081
基于剂量-反应关系的体力活动对血清肌酐水平的影响及其性别差异
Relationship between physical activity and abnormal serum creatinine levels and sex difference by dose-response association
摘要
Abstract
Aim:To explore the relationship between physical activity(PA) and the level of serum creatinine(Scr) and sex difference. Methods:Healthy individuals between 40 to 60 years old were recuited by cluster sampling method in Tangshan city;PA was assessed by the international physical activity questionnaire;Scr was measured by enzymic method using fasting blood sample. Definition of elevated Scr was >106 μmol/L in males and >97 μmol/L in females. Restricted cubic spline analysis was used to analyze the dose-response relationship between PA and Scr,and participants were alloca-ted into 4 groups accordingly; unconditional logistics regression analysis was used to explore the relationship between PA and elevated Scr. Results:A total of 2 381 participants(1 157 males,1 674 females) were enrolled in statistical analyses, and were allocated into 4 groups according to the level of PA(MET-min/week), < 129. 64, 129. 64 ~ 288. 00,>288.00~821.50, >821.50,and the number of participants were 705, 709, 804, and 613, respectively. Compared with reference group( >288.00 ~821.50) MET-min/week, participants with PA >821.50 MET-min/week had an in-creased risk for abnormal Scr in total,[OR(95% CI)] was 1.47(1.13-1.92) after adjusting other confounders. Com-pared with reference group, participants with PA <129.64 MET-min/week and PA > 821.50 MET-min/week had in-creased risks for elevated Scr in males,[OR(95% CI)] was 1.64(1.18-2.28),1.59(1.14-2.22). In females,no as-sociation was found between PA and elevated Scr(P>0.05). Conclusion:PA is non-linearly associated with Scr. Higher or lower PA may both associate with an increased risk of elevated Scr in middle-aged men.关键词
体力活动/血清肌酐/限制性立方样条/logistic模型Key words
physical activity/serum creatinine/restricted cubic spline/logistic regression model分类
医药卫生引用本文复制引用
许春杰,刘晓宇,尹素凤,郭春月,范红敏,冯福民,胡泊..基于剂量-反应关系的体力活动对血清肌酐水平的影响及其性别差异[J].郑州大学学报（医学版）,2018,53(2):225-229,5.基金项目
国家重点课题资助项目(2016YFCO900605) （2016YFCO900605）
河北省自然科学基金资助项目(H2016209042) （H2016209042）
