中国实用神经疾病杂志2017，Vol.20Issue(22)：1-4,4.DOI:10.3969/j.issn.1673-5110.2017.22.001
姜黄素治疗幼年小鼠脑外伤的实验研究
The role of CCM on traumatic brain injury in young mice
摘要
Abstract
Objective To detect whether CCM could protect the brain after TBI.Methods 92 C57BL/6 mice were divided into 3 groups randomly:Sham group,TBI+Vehicle (NaCl) group and TBI+CCM group.Construct the weight drop model which could mimic TBI.The lesion volume,motor and cognition function,the expression of β-catenin and GSK3β protein,the cell death near injury area and the neurogenesis in SGZ area were detected in each group.Results CCM treatment could decrease the volume of brain injury,improve motor function,significantly increase the number of Edu positive cells,reduce the expression of GSK3β,while increasing the expression of β-catenin (P＜0.05).Conclusion In the young mice TBI model,CCM decreased the lesion volume,promoted the motor and the cognition function,activated Notch pathway indirectivity,reduced the cell death near injury area,increased the neurogenesis in SGZ area and promoted a new method to treat TBI in young mice.关键词
幼年小鼠/脑外伤/姜黄素/神经保护/神经再生Key words
Young mice/Traumatic brain injury/CCM/Neuroprotection/Nerve regeneration分类
医药卫生引用本文复制引用
李杰,李珍,程田..姜黄素治疗幼年小鼠脑外伤的实验研究[J].中国实用神经疾病杂志,2017,20(22):1-4,4.基金项目
郑州大学第一附属医院院内青年基金,项目编号:YNQN2017042 （）
