中国实用神经疾病杂志2017，Vol.20Issue(22)：20-22,3.DOI:10.3969/j.issn.1673-5110.2017.22.006
美多芭与普拉克索治疗帕金森病的疗效分析
Observation of curative effect of metopar and dopamine receptor agonist in patients with Parkinson's disease
摘要
Abstract
Objective To investigate the clinical efficacy of methadone and dopamine receptor agonist in Parkinson's disease patients,and to observe its effect on the motor function and daily activities of patients,so as to provide a reference for clinical effec tive and safe use of drugs.Methods 78 patients with Parkinson's disease were divided into control group (62.5 mg/d,3 times/d,and 125 mg after 4 weeks,once every 6 h) and the treatment group (62.5 mg/d,3 times/d,4 weeks after the increase of 125 mg/time,taking every 6 h;dopamine receptor agonist Lyclone 0.125 mg/time,2 times/d,4 weeks can be increased to 0.25 mg/time,3times/d) according to the random number table method,each group with 39 cases;After 12 weeks of treatment,the clinical efficacy of the two groups was evaluated,and the UPDRS was used to evaluate the therapeutic effect on the daily living ability,(UPDRS Ⅱ),the motor deficiency (UPDRS Ⅲ) and complication (UPDRS Ⅳ) on the patients before treatment,8 weeks and 12 weeks after treatment respectively.Results The rate of excellent and good treatment in the treatment group was 87.18％ (34/ 39),which was significantly higher than that in the control group (58.97 ％,x2 =8.04,P =0.01).The UPDRS Ⅱ,UPDRS Ⅲ and UPDRS Ⅳ scores were significantly lower in the two groups at 8 and 12 weeks,and these scores were significantly lower in 12 weeks than that of 8 weeks.The scores of UPDRS Ⅱ,UPDRS Ⅲ and UPDRS Ⅳ in the treatment group were significantly lower than those of the control group at 8 and 12 weeks,P＜0.05.In the treatment group,the adverse reactions (10.26％ (4/39)) was significantly lower than the control group (30.77 ％,x2 =5.03,P =0.02).Conclusion The combination of methadone and dopamine receptor agonist pramipexole in patients with Parkinson's disease can improve motor function and daily living ability,and can reduce complications and adverse reactions,it can be recommended as the preferred treatment for the Parkinson's disease.关键词
帕金森/多巴胺受体激动剂/普拉克索/美多芭/运动功能/日常生活能力Key words
Parkinson's disease/Dopamine receptor agonist pramipexole/Meadoba/motor function/Daily living ability分类
医药卫生引用本文复制引用
柯来顺,蔡江萍,江华,吴欣宇,李清金,卢武生..美多芭与普拉克索治疗帕金森病的疗效分析[J].中国实用神经疾病杂志,2017,20(22):20-22,3.基金项目
福建省卫生系统中青年骨干人才培养项目(2014-ZQN-JC-38) （2014-ZQN-JC-38）
泉州市科技计划项目(2014Z23) （2014Z23）
