解放军医学杂志2018，Vol.43Issue(1)：33-37,5.DOI:10.11855/j.issn.0577-7402.2018.01.07
冠状动脉CT血管造影获得的无创血流储备分数对心肌缺血的诊断价值
Retrospective study on the diagnostic performance of noninvasive fractional flow reserve derived from coronary CT angiography for myocardial ischemia
摘要
Abstract
Objective To evaluate the diagnostic performance of noninvasive fractional flow reserve (FFR) derived from coronary computed tomographic angiography (CTA) (FFRCT) for functional myocardial ischemia.Methods Thirty-nine patients undergone coronary CTA and FFR examination from Aug.2012 to Jul.2015 in PLA General Hospital were retrospectively included in present study.Measurements of invasive FFR value was used as reference standard,and FFRCT based on coronary CTA image was performed in either per-patient or per-vessel level to assess the accuracy,specificity,sensitivity,the positive predictive value and negative predictive value for functional myocardial ischemia.Results In per-patient level,the accuracy of FFRCT was 82.05％,sensitivity was 83.33％,specificity was 80.95％,positive predictive value was 78.95％ and negative predictive value was 85.00％.In per-vessel level,the accuracy of FFRCT was 76.79％,sensitivity was 69.57％,specificity was 81.82％,positive predictive value was 72.73％ and negative predictive value was 79.41％.The area under ROC was 0.826 in per-patient level,and 0.786 in per-vessel level.For per-vessel,FFRCT was positively correlated with FFR value significantly (r=0.644;95％CI:0.458-0.775).Conclusion With FFR as reference standard,domestic noninvasive FFRCT can be used for the diagnosis of functional myocardial ischemia with high diagnostic performance and clinical application prospect.关键词
冠状动脉粥样硬化性心脏病/冠脉血流储备分数/冠状动脉/计算机体层摄影血管造影Key words
coronary atherosclerotic heart disease/coronary artery fractional flow reserve/coronary artery/computed tomography angiography分类
医药卫生引用本文复制引用
单冬凯,杨俊杰,窦冠华,荆晶,杜洛山,何柏,陈韵岱..冠状动脉CT血管造影获得的无创血流储备分数对心肌缺血的诊断价值[J].解放军医学杂志,2018,43(1):33-37,5.基金项目
国家重点研发计划项目(2016YFC1300300)This work was supported by the National Key Research and Development Program of China (2016YFC1300300) （2016YFC1300300）
