解放军医学杂志2018，Vol.43Issue(1)：51-55,5.DOI:10.11855/j.issn.0577-7402.2018.01.10
膀胱癌骨转移的相关预测及诊断因素分析
The risk factors for predicting or diagnosing bone metastases from urinary bladder neoplasms
摘要
Abstract
Objective To explore the clinical significance of some risk factor,such as blood calcium serum alkaline phosphatase (ALP) and hemoglobin (Hb) for predicting or diagnosing bone metastases from urinary bladder neoplasms.Methods A total of 35 patients diagnosed as urinary bladder neoplasms and bone metastasis based on the histopathologic analysis (bone metastasis group,BM),and 105 cases of age-,sex-and follow-up time matched urinary bladder neoplasms patients without bone metastasis (non bone metastasis group,NBM) were included in present study.The correlations between clinical-pathological parameters (blood calcium,ALP,Hb) and bone metastases from urinary bladder neoplasms were analyzed and the risk factors for predicting or diagnosing bone metastases were identified.Results The levels of blood calcium,ALP and Hb were significantly higher at first diagnosis and follow-up period in BM group than in NBM group (P＜0.05).Multivariate logistic regression analysis indicated that the levels of calcium,ALP and Hb at first diagnosis were the independent risk factors for predicting the later incidence of bone metastases (P＜0.05).The levels of calcium,ALP and Hb in follow-up period were the independent risk factors for diagnosing bone metastases (P＜0.05).Receiver operating characteristic (ROC) curves analysis showed that the levels of calcium,ALP,Hb may give a more accurate prediction on bone metastases (AUC:0.615,0.704,0.692;cut-off:2.55mmol/L,97.0U/L,101.5g/L,respectively) or diagnosing bone metastases (AUC:0.706,0.776,0.829;cut-off:2.46mmol/L,112.5U/L,103.5g/L,respectively).Conclusion The levels of blood calcium,ALP and Hb may be used to predict the risk of bone metastases for patients firstly diagnosed as urinary bladder neoplasms,and predict whether the patients will be complicated with bone metastases during follow-up period.关键词
膀胱肿瘤/骨转移/危险因素/诊断Key words
urinary bladder neoplasms/bone metastases/risk factor/diagnosing分类
医药卫生引用本文复制引用
兰敏,刘家明,徐佳佳,刘明军,陈文昭,陈宣银,黄山虎,刘志礼..膀胱癌骨转移的相关预测及诊断因素分析[J].解放军医学杂志,2018,43(1):51-55,5.基金项目
江西省科技厅人才计划项目(20162BCB22022,20162BCB23057)This work was supported by the Talent Projects of Jiangxi Provincial Department of Science and Technology (20162BCB22022,20162BCB23057) （20162BCB22022,20162BCB23057）
