临床与实验病理学杂志2017，Vol.33Issue(12)：1307-1310,4.DOI:10.13315/j.cnki.cjcep.2017.12.003
联合免疫荧光和荧光原位杂交法检测TNFAIP3基因在结外鼻型NK/T细胞淋巴瘤中的异常及意义
Significance of TNFAIP3 abnormity in natural killer/T-cell lymphoma, nasal type detected by fluorescence immunophenotyping and interphase cytogenetics
摘要
Abstract
Purpose To explore the prognostic value of deletion of the TNFAIP3 gene in natural killer/T-cell lymphoma,nasal type detected with fluorescence immunophenotyping and interphase cytogenetics as a tool for the investigation of neoplasm (FICTION).Methods FICTION was performed to detect the abnormalities of TNFAIP3 gene in 109 cases of natural killer/T-cell lymphoma,nasal type.Results TNFAIP3 deletion was found in 25/79 detectable cases.The deletion of TNFAIP3 was positively correlated with the International Prognosis Index (IPI) (P =0.019).Conclusion Frequent deletion of TNFAIP3 was associated with IPI in natural killer/T-cell lymphoma,nasal type,suggesting the important prognostic value of TNFAIP3 in the natural killer/T-cell lymphoma,nasal type.关键词
淋巴瘤/结外鼻型NK/T细胞淋巴瘤/TNFAIP3/联合免疫荧光和荧光原位杂交法Key words
lymphoma/nasal type natural killer/T-cell lymphoma/TNFAIP3/FICTION分类
医药卫生引用本文复制引用
刘芳,王映梅,李明阳,赵丹晖,李侠,刘一雄,王哲,闫庆国..联合免疫荧光和荧光原位杂交法检测TNFAIP3基因在结外鼻型NK/T细胞淋巴瘤中的异常及意义[J].临床与实验病理学杂志,2017,33(12):1307-1310,4.基金项目
国家自然科学基金(81570176) （81570176）
