临床与实验病理学杂志2017，Vol.33Issue(12)：1311-1315,5.DOI:10.13315/j.cnki.cjcep.2017.12.004
睾丸弥漫大B细胞淋巴瘤中MyD88及CD79B基因突变及意义
CD79B and MyD88 gene mutation in primary testicular diffuse large B cell lymphoma
摘要
Abstract
Purpose To explore the mutation of CD79B and MyD88 in primary testicular diffuse large B cell lymphoma and their significance.Methods Histopathologic features were observed in 15 cases of primary testicular diffuse large B cell lymphoma and immunophenotype was analyzed by immunohistochemical staining (IHC).Sanger sequencing was used to detect CD79B Y196 and MyD88 L265 mutation in these cases.The relationship between CD79B,MyD88 mutation and the clinicopathological features was analyzed.Results Immunophenotypically,15 cases were non germinal center B cell type.CD79B (Y196) mutation was detected in 4 cases (26.7％).For MyD88,L265 mutation was found in 7 cases (46.7％).CD79B and MyD88 mutations were found in 3 cases.The followup information was obtained in 8 patients.No association was found between CD79B,MyD88 mutation and outcome of patients.Conclusion Primary testicular diffuse large B cell lymphoma of non germinal center B cell type is a rare aggressive B cell lymphoma with poor prognosis and poor response to chemotherapy.CD79B,MyD88 gene mnutation was detected in Chinese patients with frequency of 26.7％ and 46.7％ respectively.It is possible for molecular targeted therapy of the primary testicular diffuse large B cell lymphoma on the basis of high frequency of CD79B and MyD88 gene mutation.关键词
睾丸肿瘤/淋巴瘤/原发性弥漫大B细胞淋巴瘤/免疫表型/MyD88基因突变/CD79B基因突变/预后Key words
testicular neoplasms/lymphoma/primary testicular diffuse large B cell lymphoma/immunophenotype/MyD88 gene mutation/CD79B gene mutation/prognosis分类
医药卫生引用本文复制引用
马世荣,刘杨,刘芳,王映梅,王哲,郭双平..睾丸弥漫大B细胞淋巴瘤中MyD88及CD79B基因突变及意义[J].临床与实验病理学杂志,2017,33(12):1311-1315,5.基金项目
国家自然科学基金(81472597) （81472597）
