临床与实验病理学杂志2017，Vol.33Issue(12)：1320-1323,4.DOI:10.13315/j.cnki.cjcep.2017.12.006
结肠腺癌中Orai1与STIM1的表达及临床意义
Expression of Orai1 and STIM1 protein in colon cancer and their clinical significance
摘要
Abstract
Purpose To investigate the expression of Orai1 and STIM1 in colon cancer and its clinical significance.Methods Immnohistochemistry was used to detect Orai1 and STIM1 protein expression level in 80 cases of colon cancer and 50 cases of normal colon epithelium.The relationships between Orai1 and STIM1 expression and prognosis were statistically analyzed.Result The expression levels of Orai1 and STIM1 in colon cancer were significantly higher than that in normal colon epithelium(P＜ 0.05).Positive expression of Orai1 and STIM1 was correlated with the TNM stage and lymph node metastasis (P ＜ 0.05),but not correlated with gender,age,and differentiation(P ＞0.05).There was a significant positive correlation between Orai1 and STIM1 expression(P =0.001,rs =0.349).Univariate analysis showed that the expression of Orai1 protein,STIM1 protein,TNM stage and lymph node metastasis were significant prognostic factors for colon cancer patients.Conclusion In colon cancer,both Orail and STIM1 proteins may have synergetic functions and promote the development of the tumor,and could be used as a novel biological indicator of anticancer therapy and prognosis.关键词
结肠肿瘤/Orai1蛋白/STIM1蛋白/预后Key words
colon neoplasms/Orai1 protein/STIM1 protein/prognosis分类
医药卫生引用本文复制引用
李艳东,朱琳,周永莉,周伊,郑建云..结肠腺癌中Orai1与STIM1的表达及临床意义[J].临床与实验病理学杂志,2017,33(12):1320-1323,4.基金项目
陕西省自然科学基础研究计划项目(2013JM4054) （2013JM4054）
