临床与实验病理学杂志2017，Vol.33Issue(12)：1324-1327,4.DOI:10.13315/j.cnki.cjcep.2017.12.007
食管癌早期基因CHMP4A及TSPYL-2在食管癌变过程中的表达及其意义
Expression of CHMP4A and TSPYL-2 in early esophageal cancer and their significance
摘要
Abstract
Purpose To investigate the role of CHMP4A and TSPYL-2 in early pathogenesis of esophageal cancer.Methods Through comparison of the four subtractive libraries,early esophageal squamous cell carcinoma genes CHMP4A and TSPYL-2 were chosen for further study.Through RT-PCR and immunohistochemistry methods,CHMP4A and TSPYL-2's expression was detected in esophageal squamous cell carcinoma tissue,cancerous tissue and normal esophageal mucosa.Results CHMP4A and TSPYL-2 expression between esophageal squamous cell carcinoma and normal esophageal epithelium tissue had significant differences (P ＜ 0.05),and the CHMP4A gene expression in esophageal mucosa,field cancerization areas,esophageal squamous cell carcinoma tissue increased,while TSPYL-2 gene expression in esophageal mucosa,field cancerization areas,esophageal squamous cell carcinoma tissue decreased,which were consistent with the protein expression of CHMP4A and TSPYL-2.Conclusion CHMP4A and TSPYL-2 genes are differentially expressed in esophageal squamous cell carcinoma,which can be used as alternative genetic markers for further research.关键词
食管肿瘤/鳞状细胞癌/癌化区域/抑制消减杂交/CHMP4A/TSPYL-2Key words
esophageal neoplasms/squamous cell carcinoma/field cancerization/suppression subtractive hybridization/CHMP4A/TSPYL-2分类
医药卫生引用本文复制引用
杨荣,熊海科,尚丽娜,马桂,宋丽娟,杨春霞,刘玮,何欣,康雅琼,罗雁..食管癌早期基因CHMP4A及TSPYL-2在食管癌变过程中的表达及其意义[J].临床与实验病理学杂志,2017,33(12):1324-1327,4.基金项目
甘肃省自然科学基金(1308RJZA155) （1308RJZA155）
