国际眼科杂志2018，Vol.18Issue(4)：649-651,3.DOI:10.3980/j.issn.1672-5123.2018.4.13
可溶性VEGF受体1在视网膜新生血管疾病中的研究进展
Research on soluble VEGF receptor 1 in retinal neovascularization
摘要
Abstract
·The common feature of retinal neovascularization is the formation of pathological neovascularization. The primary one of endogenous retinal neovascularization factor in current research is vascular endothelial growth factor (VEGF). SFlt-1, the soluble form of splicing in mRNA extracellular region of VEGFR - 1, which is short of intracellular tyrosine kinase domain can only encode the extracellular domain. Therefore, it only can bind with ligands but can not transmit signals, thus preventing the formation of neovascularization. SFlt-1,as a hot research topic in recent years, may provide a new gene therapy method for this disease. This review focus on the mechanism and research progress of sFlt-1 in retinal neovascularization.关键词
血管内皮生长因子/可溶性血管内皮生长因子受体1/视网膜新生血管Key words
vascular endothelial growth factor/soluble vascular endothelial growth factor receptor 1/retinal neovascularization引用本文复制引用
崔晓媛,徐国兴..可溶性VEGF受体1在视网膜新生血管疾病中的研究进展[J].国际眼科杂志,2018,18(4):649-651,3.基金项目
福建省社会发展高校产学合作项目(No.2014Y4003) Industry-Academy Cooperation Project for Social Development of Fujian Province(No.2014Y4003) （No.2014Y4003）
