国际眼科杂志2018，Vol.18Issue(4)：682-685,4.DOI:10.3980/j.issn.1672-5123.2018.4.22
全视网膜光凝联合雷珠单抗与曲安奈德治疗糖尿病黄斑水肿的疗效及费用比较
Clinical effect and cost analysis of panretinal photocoagulation combined with Ranibizumab or triamcinolone acetonide for diabetic macular edema
摘要
Abstract
·AIM: To compare clinical effects and cost of panretinal photocoagulation (PRP) combined with Ranibizumab or triamcinolone acetonide (TA) for diabetic macular edema (DME). ·METHODS: Forty-eight patients (48 eyes) with DME and diabetic retinopathy ( DR) receiving PRP were randomly assigned to two groups, which were respectively intravitreally injected ranibizumab (0. 5mg) and TA (4mg). Ranibizumab (0.5mg) was intravitreal injected every 4wk for 3 times. The effects of injection for DME were evaluated using best-corrected visual acuity (BCVA ), central macular thickness ( CMT ) and intraocular pressure (IOP). During the follow-up, other injections were performed to eyes which had CMT greater than 400μ m. The medical costs were calculated at 12wk and 24wk.·RESULTS: BCVA and CMT between 2 groups were not significantly different (P>0.05); BCVA and CMT among different time points were significantly different(P<0.05);the treatments and the time points had significant interaction on BCVA (P<0.05). BCVA was improved in two groups at all the time after injection(P<0.05),except 1wk after injection of TA (P=0.33). There was significant difference between the two groups at 12wk and 16wk on BCVA and that injected with ranibizumab was better (P=0.03,0.045). CMT decreased in two groups at all the time after injection (P<0.05). There was significant difference only between the two groups at 1wk (P< 0. 01). All intraocular pressures were in the normal range, except one needed ocular hypotensive agents. The medical costs (yuan) of the ranibizumab group in 12wk and 24wk were 38 736 and 42 564,which of the TA group were 5 790 and 7 053,respectively. ·CONCLUSION:Both PRP combined with ranibizumab or TA for DME can effectively control disease progression in short time. Therapeutic effect is not significant between two methods, but PRP combined with TA is more economic.关键词
糖尿病黄斑水肿/雷珠单抗/曲安奈德/玻璃体腔注射/全视网膜光凝Key words
diabetic macular edema/ranibizumab/triamcinolone acetonide/intravitreal injection/panretinal photocoagulation引用本文复制引用
潘竹娟,张志辉,樊飞红,郑晓柯,齐文娟..全视网膜光凝联合雷珠单抗与曲安奈德治疗糖尿病黄斑水肿的疗效及费用比较[J].国际眼科杂志,2018,18(4):682-685,4.基金项目
广州市卫生局医药卫生科技立项基金(No.2016A010097) 2016 Medical Research Foundation of Health and Family Planning Commission of Guangzhou Municipality(No.2016A010097) （No.2016A010097）
