青岛大学医学院学报2017，Vol.53Issue(5)：515-518,4.DOI:10.13361/j.qdyxy.201705004
山东汉族孕妇XPC基因rs2228001位点多态性与子痫前期遗传易感性的相关性
ASSOCIATION BETWEEN POLYMORPHISM OF RS2228001 IN XPC GENE AND GENETIC SUSCEPTIBILITY TO PREECLAMPSIA IN HAN PREGNANT WOMEN IN SHANDONG PROVINCE, CHINA
摘要
Abstract
Objective To investigate the association between the polymorphism of rs2228001 in the XPC gene and genetic susceptibility to preeclampsia.Methods A total of 1 279 normal pregnant women in Shandong Province,China were enrolled as control group,and 978 pregnant women with preeclampsia were enrolled as case group.Quantitative real-time PCR was used to detect rs2228001,and the genotype and allele frequencies of rs2228001 were compared between the two groups to analyze the association between the single nucleotide polymorphism of rs2228001 in the XPC gene and genetic susceptibility to preeclampsia.Results There were no significant differences in the genotype and allele frequencies of rs2228001 in the XPC gene between the case group and the control group (P＞0.05).There were no significant differences in the distribution of genotypes and allele frequencies of rs2228001 between the early-/late-onset preeclampsia groups and the control group,as well as between the mild/severe preeclampsia groups and the control group (P ＞ 0.05).Conclusion There is no association between the polymorphism of rs2228001 in the XPC gene and genetic susceptibility to preeclampsia.关键词
着色性干皮病基因组C/先兆子痫/多态性,限制性片段长度/疾病遗传易感性Key words
xeroderma pigmentosum group C/pre-eclampsia/polymorphism, restriction fragment length/genetic predisposition to disease分类
临床医学引用本文复制引用
吴宇文,侯琳,王敬丽,刘世国,王梦瑶..山东汉族孕妇XPC基因rs2228001位点多态性与子痫前期遗传易感性的相关性[J].青岛大学医学院学报,2017,53(5):515-518,4.基金项目
山东省自然科学基金资助项目(ZR2016MH28) （ZR2016MH28）
