青岛大学医学院学报2017，Vol.53Issue(5)：523-527,5.DOI:10.13361/j.qdyxy.201705006
个体化饮食干预对PCOS不孕病人IR及妊娠影响
EFFECT OF INDIVIDUALIZED DIETARY INTERVENTION ON INSULIN RESISTANCE AND PREGNANCY IN INFERTILE PATIENTS WITH POLYCYSTIC OVARY SYNDROME
摘要
Abstract
Objective To investigate the effect of individualized dietary intervention on insulin resistance (IR) and pregnancy in infertile patients with polycystic ovary syndrome (PCOS).Methods A total of 179 infertile patients with PCOS were enrolled and randomly divided into observation group with 97 patients and control group with 82 patients.The patients in the control group were treated with ethinylestradiol and cyproterone acetate tablets (Diane-35) combined with metformin,and those in the observation group were treated with Diane-35 combined with individualized dietary intervention.The two groups were compared in terms of the changes in glucose metabolism indices and sex hormone levels after intervention,and follow-up was performed to obtain ovulation rate and pregnancy rate.Results After intervention,the observation group had significantly lower body mass index (BMI),body weight (WT),and waist-to-hip ratio (WHR) than the control group (t=5.340-7.565,P＜0.05),while there were no significant differences between the two groups in fasting blood glucose,fasting insulin,homeostasis model assessment of insulin resistance,serum testosterone,luteinizing hormone,follicle-stimulating hormone,and LH/FSH (P＞0.05).The observation group had significantly higher menstruation normalization rate,ovulation rate,and pregnancy rate than the control group (x2 =4.121-9.717,P＜0.05).Conclusion Individualized dietary intervention can reduce BMI,WT,and WHR of infertile patients with PCOS,improve the reproductive endocrine environment,restore menstrual cycle,and improve ovulation rate and pregnancy rate without any side effect,and therefore,it is suitable for long-term application.关键词
多囊卵巢综合征/胰岛素抗药性/个体化饮食干预/妊娠Key words
polycystic ovary syndrome/insulin resistance/individualized dietary intervention/pregnancy分类
医药卫生引用本文复制引用
葛秋迎,于艳丽,刘秀荣..个体化饮食干预对PCOS不孕病人IR及妊娠影响[J].青岛大学医学院学报,2017,53(5):523-527,5.基金项目
河北省卫生和计划生育委员会医学科学研究课题计划项目(13010520171117) （13010520171117）
